Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Preparation of (Re-188) Re-AEDP and its biodistribution studies | |
| Li, QN（李晴暖）; Zhang, XD（张晓东）; Sheng, R; Li, WX（李文新） | |
| 2000 | |
| Source Publication | APPLIED RADIATION AND ISOTOPES
 |
| ISSN | 0969-8043 |
| Volume | 53Issue:6Pages:993 |
| Abstract | The synthesis of the Re (V) complex and preparation of Re-188-AEDP are described using Re-188 which was obtained from the alumina-based W-188/Re-188 generator. Dependence of the radiolabeling yields of Re-188-AEDP on reducing agent concentration, AEDP concentration, pH and addition of carrier was examined. In the case of optimum conditions, the radiolabeling yields of Re-188-AEDP were 92-93% for carrier-free Re-188 and 95-98% for carrier-added Re-188. The stability of Re-188-AEDP at pH approximate to 6 was studied and it is found that the carrier has a significant effect on the stability of Re-188-AEDP. The biodistribution of carrier-free and carrier-added Re-188-labelled compounds in rats was also measured. The results show that Re-188 (carrier-added)-AEDP is a potential bone palliation radiopharmaceutical due to its high skeletal uptake, rapid blood clearance and relatively low soft tissue absorption. (C) 2000 Elsevier Science Ltd. All rights reserved. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000089793200005 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/10114 |
| Collection | 中科院上海原子核所2003年前 |
| Recommended Citation GB/T 7714 | Li, QN,Zhang, XD,Sheng, R,et al. Preparation of (Re-188) Re-AEDP and its biodistribution studies[J]. APPLIED RADIATION AND ISOTOPES,2000,53(6):993. |
| APA | Li, QN,Zhang, XD,Sheng, R,&Li, WX.(2000).Preparation of (Re-188) Re-AEDP and its biodistribution studies.APPLIED RADIATION AND ISOTOPES,53(6),993. |
| MLA | Li, QN,et al."Preparation of (Re-188) Re-AEDP and its biodistribution studies".APPLIED RADIATION AND ISOTOPES 53.6(2000):993. |
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| Preparation of (Re-1（138KB） | 开放获取 | -- | View Application Full Text | |||
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