CAS OpenIR  > 中科院上海原子核所2003年前
Preparation of (Re-188) Re-AEDP and its biodistribution studies
Li, QN(李晴暖); Zhang, XD(张晓东); Sheng, R; Li, WX(李文新)
2000
Source PublicationAPPLIED RADIATION AND ISOTOPES
ISSN0969-8043
Volume53Issue:6Pages:993
AbstractThe synthesis of the Re (V) complex and preparation of Re-188-AEDP are described using Re-188 which was obtained from the alumina-based W-188/Re-188 generator. Dependence of the radiolabeling yields of Re-188-AEDP on reducing agent concentration, AEDP concentration, pH and addition of carrier was examined. In the case of optimum conditions, the radiolabeling yields of Re-188-AEDP were 92-93% for carrier-free Re-188 and 95-98% for carrier-added Re-188. The stability of Re-188-AEDP at pH approximate to 6 was studied and it is found that the carrier has a significant effect on the stability of Re-188-AEDP. The biodistribution of carrier-free and carrier-added Re-188-labelled compounds in rats was also measured. The results show that Re-188 (carrier-added)-AEDP is a potential bone palliation radiopharmaceutical due to its high skeletal uptake, rapid blood clearance and relatively low soft tissue absorption. (C) 2000 Elsevier Science Ltd. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000089793200005
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/10114
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
Li, QN,Zhang, XD,Sheng, R,et al. Preparation of (Re-188) Re-AEDP and its biodistribution studies[J]. APPLIED RADIATION AND ISOTOPES,2000,53(6):993.
APA Li, QN,Zhang, XD,Sheng, R,&Li, WX.(2000).Preparation of (Re-188) Re-AEDP and its biodistribution studies.APPLIED RADIATION AND ISOTOPES,53(6),993.
MLA Li, QN,et al."Preparation of (Re-188) Re-AEDP and its biodistribution studies".APPLIED RADIATION AND ISOTOPES 53.6(2000):993.
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