CAS OpenIR  > 中科院上海原子核所2003年前
Preparation of [Re-188]Rhenium sulfide suspension and its biodistribution following intra-tumor injection in mice
Yu, JF(于俊锋); Yin, DZ(尹端沚); Min, XF(闵小锋); Guo, ZL; Zhang, J; Wang, YX(汪勇先); Knapp, FF
1999
Source PublicationJOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN0362-4803
Volume42Issue:3Pages:233
Abstract[Re-188]Rhenium sulfide suspension was prepared by the reaction of Na2S2O3 and KReO4 containing (NaReO4)-Re-188 in acid solution and assessed for its applicability in tumor treatment by the techniques of radioisotope interventional therapy. The reaction conditions such as the concentration ratio of Na2S2O3, to KReO4, heating time, ultrasonic time were optimized. The radiochemical yield of [Re-188]Rhenium sulfide suspension is more than 96% and in vitro stability studies demonstrated that more than 99% of the 188Re remained in sulfide form over a 72hrs period. The main particle size after various ultrasonic times is 1-5 mu m. [Re-188]Rhenium sulfide suspension was injected into tumors and the tumor-bearing mice were killed after some time to determine the retention of Re-188 in tumor and the leakage to different organs by gamma counter. The mean retention percentages of Re-188 in tumors were 83.08 +/- 13.71%, 83.92 +/- 9.79%, 80.23 +/- 3.82% and 78.75 +/- 3.02% at Ih, 24, 48 and 72hrs respectively. After 72hrs the highest activity outside the tumors was in the liver, spleen and the kidneys. Our preliminary results indicated that [Re-188]Rhenium sulfide suspension may be an effective radiopharmaceutical for tumor treatment by the techniques of radioisotope interventional therapy.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000078818900004
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/10115
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
Yu, JF,Yin, DZ,Min, XF,et al. Preparation of [Re-188]Rhenium sulfide suspension and its biodistribution following intra-tumor injection in mice[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,1999,42(3):233.
APA Yu, JF.,Yin, DZ.,Min, XF.,Guo, ZL.,Zhang, J.,...&Knapp, FF.(1999).Preparation of [Re-188]Rhenium sulfide suspension and its biodistribution following intra-tumor injection in mice.JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,42(3),233.
MLA Yu, JF,et al."Preparation of [Re-188]Rhenium sulfide suspension and its biodistribution following intra-tumor injection in mice".JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 42.3(1999):233.
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