CAS OpenIR  > 中科院上海原子核所2003年前
Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies
Li, QN(李晴暖); Xiu, Y; Zhang, XD(张晓冬); Liu, RL(刘瑞丽); Du, QQ; Shun, XG; Chen, SL; Li, WX(李文新)
2002
Source PublicationNUCLEAR MEDICINE AND BIOLOGY
ISSN0969-8051
Volume29Issue:6Pages:707
AbstractThe biological behavior of fullerene derivatives shows their considerable potential for medical applications. In order to provide a C-60 derivative for biodistriburtion studies, the Tc-99m-labeling of C-60(OH)(x) was optimized. Gamma counting and single photon emission computed tomography (SPECT) were used to assess the biodistribution of the Tc-99m-labeled compound in mice and rabbits. Biodistribution studies in mice and imaging of rabbits indicated that Tc-99m-C-60(OH)(x) was widely distributed in all tissues. A significant percentage of total activity was retained for 48 h, particularly in the kidneys, bone, spleen, and liver. All tissues displayed a slow clearance over 48 h, except for bone, which showed slightly increasing localization within 24 h. (C) 2002 Elsevier Science Inc. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000177372100012
Citation statistics
Cited Times:74[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/10121
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
Li, QN,Xiu, Y,Zhang, XD,et al. Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies[J]. NUCLEAR MEDICINE AND BIOLOGY,2002,29(6):707.
APA Li, QN.,Xiu, Y.,Zhang, XD.,Liu, RL.,Du, QQ.,...&Li, WX.(2002).Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies.NUCLEAR MEDICINE AND BIOLOGY,29(6),707.
MLA Li, QN,et al."Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies".NUCLEAR MEDICINE AND BIOLOGY 29.6(2002):707.
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