Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies | |
| Li, QN（李晴暖）; Xiu, Y; Zhang, XD（张晓冬）; Liu, RL（刘瑞丽）; Du, QQ; Shun, XG; Chen, SL; Li, WX（李文新） | |
| 2002 | |
| Source Publication | NUCLEAR MEDICINE AND BIOLOGY
 |
| ISSN | 0969-8051 |
| Volume | 29Issue:6Pages:707 |
| Abstract | The biological behavior of fullerene derivatives shows their considerable potential for medical applications. In order to provide a C-60 derivative for biodistriburtion studies, the Tc-99m-labeling of C-60(OH)(x) was optimized. Gamma counting and single photon emission computed tomography (SPECT) were used to assess the biodistribution of the Tc-99m-labeled compound in mice and rabbits. Biodistribution studies in mice and imaging of rabbits indicated that Tc-99m-C-60(OH)(x) was widely distributed in all tissues. A significant percentage of total activity was retained for 48 h, particularly in the kidneys, bone, spleen, and liver. All tissues displayed a slow clearance over 48 h, except for bone, which showed slightly increasing localization within 24 h. (C) 2002 Elsevier Science Inc. All rights reserved. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000177372100012 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/10121 |
| Collection | 中科院上海原子核所2003年前 |
| Recommended Citation GB/T 7714 | Li, QN,Xiu, Y,Zhang, XD,et al. Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies[J]. NUCLEAR MEDICINE AND BIOLOGY,2002,29(6):707. |
| APA | Li, QN.,Xiu, Y.,Zhang, XD.,Liu, RL.,Du, QQ.,...&Li, WX.(2002).Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies.NUCLEAR MEDICINE AND BIOLOGY,29(6),707. |
| MLA | Li, QN,et al."Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies".NUCLEAR MEDICINE AND BIOLOGY 29.6(2002):707. |
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