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Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies | |
Li, QN(李晴暖); Xiu, Y; Zhang, XD(张晓冬); Liu, RL(刘瑞丽); Du, QQ; Shun, XG; Chen, SL; Li, WX(李文新) | |
2002 | |
Source Publication | NUCLEAR MEDICINE AND BIOLOGY
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ISSN | 0969-8051 |
Volume | 29Issue:6Pages:707 |
Abstract | The biological behavior of fullerene derivatives shows their considerable potential for medical applications. In order to provide a C-60 derivative for biodistriburtion studies, the Tc-99m-labeling of C-60(OH)(x) was optimized. Gamma counting and single photon emission computed tomography (SPECT) were used to assess the biodistribution of the Tc-99m-labeled compound in mice and rabbits. Biodistribution studies in mice and imaging of rabbits indicated that Tc-99m-C-60(OH)(x) was widely distributed in all tissues. A significant percentage of total activity was retained for 48 h, particularly in the kidneys, bone, spleen, and liver. All tissues displayed a slow clearance over 48 h, except for bone, which showed slightly increasing localization within 24 h. (C) 2002 Elsevier Science Inc. All rights reserved. |
Indexed By | SCI |
Language | 英语 |
Funding Project | 应物所项目组 |
WOS ID | WOS:000177372100012 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.sinap.ac.cn/handle/331007/10121 |
Collection | 中科院上海原子核所2003年前 |
Recommended Citation GB/T 7714 | Li, QN,Xiu, Y,Zhang, XD,et al. Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies[J]. NUCLEAR MEDICINE AND BIOLOGY,2002,29(6):707. |
APA | Li, QN.,Xiu, Y.,Zhang, XD.,Liu, RL.,Du, QQ.,...&Li, WX.(2002).Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies.NUCLEAR MEDICINE AND BIOLOGY,29(6),707. |
MLA | Li, QN,et al."Preparation of Tc-99m-C-60(OH)(x) and its biodistribution studies".NUCLEAR MEDICINE AND BIOLOGY 29.6(2002):707. |
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