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| Radiolabeling of magnetic targeted carriers (MTC) with indium-111 | |
| Hafeli, UO; Yu, JF（于俊锋）; Farudi, F; Li, YH; Tapolsky, G | |
| 2003 | |
| Source Publication | NUCLEAR MEDICINE AND BIOLOGY
 |
| ISSN | 0969-8051 |
| Volume | 30Issue:7Pages:761 |
| Abstract | Magnetic targeted carriers (MTC) are magnetically susceptible microparticles that can be physically targeted to a specific site. MTC were radiolabeled with In-111 using three different methods. Reaction parameters were investigated in order to optimize the final properties of the labeled MTC. The reaction parameters studied were chelation agent, chelation time, temperature, radiolabeling time, solvent, and molar ratios. A 97.7 +/- 0.9% binding efficiency and plasma stability of 92.6 +/- 0.1% over 7 days were achieved when 2-p-aminobenzyl-1,4,7, 10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (ABz-DOTA) was used as the chelating agent. A preliminary animal biodistribution study confirmed the binding stability. The labeling of the MTC with the diagnostic isotope In-111 was undertaken to allow for quantitative imaging and dosimetry prior to therapy with Y-90 radiolabeled MTC. (C) 2003 Elsevier Inc. All rights reserved. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000185746200011 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/10139 |
| Collection | 中科院上海原子核所2003年前 |
| Recommended Citation GB/T 7714 | Hafeli, UO,Yu, JF,Farudi, F,et al. Radiolabeling of magnetic targeted carriers (MTC) with indium-111[J]. NUCLEAR MEDICINE AND BIOLOGY,2003,30(7):761. |
| APA | Hafeli, UO,Yu, JF,Farudi, F,Li, YH,&Tapolsky, G.(2003).Radiolabeling of magnetic targeted carriers (MTC) with indium-111.NUCLEAR MEDICINE AND BIOLOGY,30(7),761. |
| MLA | Hafeli, UO,et al."Radiolabeling of magnetic targeted carriers (MTC) with indium-111".NUCLEAR MEDICINE AND BIOLOGY 30.7(2003):761. |
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