CAS OpenIR  > 中科院上海原子核所2003年前
Radiolabeling of magnetic targeted carriers (MTC) with indium-111
Hafeli, UO; Yu, JF(于俊锋); Farudi, F; Li, YH; Tapolsky, G
2003
Source PublicationNUCLEAR MEDICINE AND BIOLOGY
ISSN0969-8051
Volume30Issue:7Pages:761
AbstractMagnetic targeted carriers (MTC) are magnetically susceptible microparticles that can be physically targeted to a specific site. MTC were radiolabeled with In-111 using three different methods. Reaction parameters were investigated in order to optimize the final properties of the labeled MTC. The reaction parameters studied were chelation agent, chelation time, temperature, radiolabeling time, solvent, and molar ratios. A 97.7 +/- 0.9% binding efficiency and plasma stability of 92.6 +/- 0.1% over 7 days were achieved when 2-p-aminobenzyl-1,4,7, 10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (ABz-DOTA) was used as the chelating agent. A preliminary animal biodistribution study confirmed the binding stability. The labeling of the MTC with the diagnostic isotope In-111 was undertaken to allow for quantitative imaging and dosimetry prior to therapy with Y-90 radiolabeled MTC. (C) 2003 Elsevier Inc. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000185746200011
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/10139
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
Hafeli, UO,Yu, JF,Farudi, F,et al. Radiolabeling of magnetic targeted carriers (MTC) with indium-111[J]. NUCLEAR MEDICINE AND BIOLOGY,2003,30(7):761.
APA Hafeli, UO,Yu, JF,Farudi, F,Li, YH,&Tapolsky, G.(2003).Radiolabeling of magnetic targeted carriers (MTC) with indium-111.NUCLEAR MEDICINE AND BIOLOGY,30(7),761.
MLA Hafeli, UO,et al."Radiolabeling of magnetic targeted carriers (MTC) with indium-111".NUCLEAR MEDICINE AND BIOLOGY 30.7(2003):761.
Files in This Item: Download All
File Name/Size DocType Version Access License
Radiolabeling of mag(224KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hafeli, UO]'s Articles
[Yu, JF(于俊锋)]'s Articles
[Farudi, F]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hafeli, UO]'s Articles
[Yu, JF(于俊锋)]'s Articles
[Farudi, F]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hafeli, UO]'s Articles
[Yu, JF(于俊锋)]'s Articles
[Farudi, F]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Radiolabeling of magnetic targeted carriers (MTC) with indium-111.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.