CAS OpenIR  > 中科院上海原子核所2003年前
Redox reactions of etoposide in aqueous solution - A pulse radiolysis and laser flash photolysis study
Lu, CY(陆长元); Han, ZH(韩镇辉); Lin, WZ(林维真); Wang, WF(王文锋); Yao, SD(姚思德); Lin, NY(林念芸)
2000
Source PublicationACTA CHIMICA SINICA
ISSN0567-7351
Volume58Issue:1Pages:29
AbstractTime - resolved pulse radiolysis has been used to study the reactions of etoposide (VP 16) with N-3(.) , (SCN)2(. -), e(aq)(-) in aqueous solution. The absorption spectra of reaction products were investigated, and a series of rate constants were determined to be 2 . 7 x 10(9), 3 . 2 x 10(9), 2 . 5 x 10(8) dm(3) . mol (- 1) . s (- 1) for reactions of e(aq)(-) N-3(.) , (SCN)(2)(. -) with etoposide, respectively. Using laser flash photolysis techniques, it is demonstrated that VP16 in aqueous solution is ionized by 248 nm photon to give hydrated electron and neutral radical resulting from rapid deprotonation of radical cation of etoposide. The pK value of VP16 is found to be 10 . 6, and the rate constants for reaction of VP16 with SO4. - is 2 . 8 x 10(9) dm(3) . mol (- 1). s (- 1).
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000084780600006
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/10145
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
Lu, CY,Han, ZH,Lin, WZ,et al. Redox reactions of etoposide in aqueous solution - A pulse radiolysis and laser flash photolysis study[J]. ACTA CHIMICA SINICA,2000,58(1):29.
APA Lu, CY,Han, ZH,Lin, WZ,Wang, WF,Yao, SD,&Lin, NY.(2000).Redox reactions of etoposide in aqueous solution - A pulse radiolysis and laser flash photolysis study.ACTA CHIMICA SINICA,58(1),29.
MLA Lu, CY,et al."Redox reactions of etoposide in aqueous solution - A pulse radiolysis and laser flash photolysis study".ACTA CHIMICA SINICA 58.1(2000):29.
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