CAS OpenIR  > 中科院上海原子核所2003年前
Structural transformation and aggregation of human alpha-synuclein in trifluoroethanol: Non-amyloid component sequence is essential and beta-sheet formation is prerequisite to aggregation
Li, HT; Du, HN; Tang, L(唐琳); Hu, J(胡钧); Hu, HY
2002
Source PublicationBIOPOLYMERS
ISSN0006-3525
Volume64Issue:4Pages:221
AbstractAmyloid-like aggregation of alpha-synuclein and deposit in Lewy bodies arc thought to be the major cause of Parkinson's disease. Here we describe the secondary structural transformation and aggregation of human alpha-synuclein and its C-terminus truncated fragments in trifluoroethanol. Proteins containing the NAC (non-amyloid component) segment undergo a three-state transition: from native random coil to beta-sheet and to alpha-helical structure, while the NAC deficient fragment and gamma-synuclein undergo a typical two-state coil-to-alpha transition. The beta-sheet form is highly hydrophobic that strongly binds to 1-anilinonaphthalene-8-sulfonic acid (ANS) and is prone to self-aggregation. The results suggest that the NAC sequence is essential to beta-sheet formation and the aggregation originates from the beta-sheet intermediate, which may be implicated in the pathogenesis of Parkinson's disease. (C) 2002 Wiley Periodicals, Inc.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000176388900005
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/10173
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
Li, HT,Du, HN,Tang, L,et al. Structural transformation and aggregation of human alpha-synuclein in trifluoroethanol: Non-amyloid component sequence is essential and beta-sheet formation is prerequisite to aggregation[J]. BIOPOLYMERS,2002,64(4):221.
APA Li, HT,Du, HN,Tang, L,Hu, J,&Hu, HY.(2002).Structural transformation and aggregation of human alpha-synuclein in trifluoroethanol: Non-amyloid component sequence is essential and beta-sheet formation is prerequisite to aggregation.BIOPOLYMERS,64(4),221.
MLA Li, HT,et al."Structural transformation and aggregation of human alpha-synuclein in trifluoroethanol: Non-amyloid component sequence is essential and beta-sheet formation is prerequisite to aggregation".BIOPOLYMERS 64.4(2002):221.
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