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硫-35标记单克隆抗体及其制备方法
吴元芳; 周桢堂; 张雨龙; 庄道玲; 要福增
Date Available2013-01-23
Country中国
Subtype发明专利
Abstract一种硫-35标记的单克隆抗体SZ39(35S-McAb-SZ39)是 放射性35S标记的对氨基苯磺酸与单克隆抗体SZ39的交 联物。其制备方法分二步进行,首先H235SO4与苯胺 合成35S-对氨基苯磺酸,然后用碳二亚胺法由35S-对 氨基苯磺酸与McAb-SZ39交联而成。35S-McAb-SZ39能 良好地保持单抗的免疫活性,并具有与人脑胶质瘤特异结合的特 性,对肿瘤细胞杀伤力强,而对正常细胞组织及周围人员无损 伤,因此应用于制备放射性导向治疗人脑胶质瘤的医药制品 有良好的前景。
Subject AreaC07k16/00 ; A61k51/10
Funding Project应物所课题组
Language中文
Status20050511 专利权的终止 未缴年费专利权终止
Application NumberCN98110705
Patent Agent费开逵
Document Type专利
Identifierhttp://ir.sinap.ac.cn/handle/331007/10422
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
吴元芳,周桢堂,张雨龙,等. 硫-35标记单克隆抗体及其制备方法.
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