CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
一种放射性铼标记人纤溶酶原kringle5蛋白及其制备方法
李彪; 曹本红; 张岚
Date Available2013-01-23
Country中国
Subtype发明专利
Abstract本发明公开了一种188Re-rhk5蛋白及其制备方法,三羰基铼标记法采用组氨酸作为双功能螯合剂,间接标记rhk5,不与二硫键作用,保留了rhk5蛋白活性。核素188Re标记rhk5,通过核素的β射线及交叉火力作用,不但增强抗肿瘤血管生成作用、减少了药物用量,而且弥补了靶向性的不足。
Subject AreaC12n9/68 ; C12n15/57 ; C12n15/63 ; A61k38/48 ; A61p35/00
Funding Project应物所课题组
Language中文
Status20120125 实质审查的生效
Application NumberCN201010193053
Patent Agent翟羽
Document Type专利
Identifierhttp://ir.sinap.ac.cn/handle/331007/10643
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
李彪,曹本红,张岚. 一种放射性铼标记人纤溶酶原kringle5蛋白及其制备方法.
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