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~(186)Re对抗人脑胶质瘤单克隆抗体的标记条件及其体外稳定性研究
俎建华; 吴元芳; 董墨; 李惠源; 张雨龙
1999-11-10
Source Publication核技术
Issue11
Abstract用186Re对抗人脑胶质瘤单克隆抗体(MAbSZ39)进行了标记。研究了影响标记率的多种因素:如不同转移螯合剂、不同反应时间、pH及不同的SZ39还原剂等;最终找到了最佳反应条件;选用低pH的葡萄糖酸钠-盐酸缓冲溶液;标记率高达96.2%。通过测量相同反应条件下标记率;发现186Re比活度太低明显降低标记率。标记物进行了高效液相分离与纯化;并对纯化物作了体外稳定性测试;测定了不同条件下放化纯度随放置时间的变化关系。
Indexed ByCNKI
Language中文
Funding Project原子核所项目组
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/10708
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
俎建华,吴元芳,董墨,等. ~(186)Re对抗人脑胶质瘤单克隆抗体的标记条件及其体外稳定性研究[J]. 核技术,1999(11).
APA 俎建华,吴元芳,董墨,李惠源,&张雨龙.(1999).~(186)Re对抗人脑胶质瘤单克隆抗体的标记条件及其体外稳定性研究.核技术(11).
MLA 俎建华,et al."~(186)Re对抗人脑胶质瘤单克隆抗体的标记条件及其体外稳定性研究".核技术 .11(1999).
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