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~3H-黄柏,~3H-小檗碱的经皮渗透
金锡鹏; 俞小忠; 张年宝; 匡建文
1992-04-01
Source Publication同位素
Issue01
Abstract采用放射性~3H标记黄柏提取物及主要组分小檗碱;利用离体皮肤渗透装置;进行离体皮肤渗透研究。对实验结果作数学模型分析。研究发现黄柏液和小檗碱水溶液或乙二醇溶液在0.99μg/cm~2和0.82μg/cm~2以上剂量组可经豚鼠皮肤和人皮渗透。黄柏水溶液高剂量组33.50μg/cm~2经豚鼠皮肤在10h的渗透速率和渗透率分别为1.30ng/min·cm~2和2.33%.比人皮0.77ng/min·cm~2和1.38为快。小檗碱水溶液高剂量组28.64μg/cm~2在9.5h经豚鼠的渗透速率和渗透率为0.45ng/min·cm和0.89%;比经人皮0.22ng/min·cm~2和0.46%快。用乙二醇作溶剂时;可显著加快黄柏、小檗碱经豚鼠皮肤的穿透。用数学方法分析求得通透常数K_p;发现黄柏、小檗碱乙二醇溶液经豚鼠皮K_p>其相应的水溶液的K_p;黄柏、小檗碱水溶液经人皮的K_p>经豚鼠皮肤的K_p.K_P值与相应的渗透速率、渗透量相一致。黄柏和小檗碱水溶液或乙二醇溶液经人皮吸收的延搁期>经豚鼠的延搁期。
Indexed ByCNKI
Language中文
Funding Project原子核所项目组
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/10770
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
金锡鹏,俞小忠,张年宝,等. ~3H-黄柏,~3H-小檗碱的经皮渗透[J]. 同位素,1992(01).
APA 金锡鹏,俞小忠,张年宝,&匡建文.(1992).~3H-黄柏,~3H-小檗碱的经皮渗透.同位素(01).
MLA 金锡鹏,et al."~3H-黄柏,~3H-小檗碱的经皮渗透".同位素 .01(1992).
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