CAS OpenIR  > 中科院上海原子核所2003年前
DNA与2-甲基-1,4-萘醌三重态相互作用生成阴、阳离子自由基对的直接检测
马建华; 林维真; 韩镇辉; 姚思德; 林念芸
2000-08-10
Source Publication辐射研究与辐射工艺学报
Issue03
Other AbstractThe interaction of 2-methyl-1;4-naphthoquinone (MQ) with nucleotides and DNA have been studied using KrF laser photolysis aimed at elucidation of the initial reaction mechanism. Laser spectroscopy demonstrates directly that the initial species from interaction of MQ with nucleotides are radical canons of nucleotides and MQ radical anion. Kinetic analysis indicates that formation of ion pair from interaction of any of mucleotides with MQ is synchronous with decay of triplet MQ; which has provided dynamic evidence for initiation of election transfer from DNA bases to triplet MQ; while the oxidation of TMP with slowest rate could be the rate determining step during the interaction of triplet MQ with DNA. Moreover direct observation of stabilized DNA guanyl radical canon from interaction of MQ with DNA has provided initial evidence for selective cleavage of DNA at guanine moiety; which has simulated the major; initial species produced by the action of ionizing radiation or UV light on DNA.
Indexed ByCNKI
Language中文
Funding Project原子核所项目组
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/10910
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
马建华,林维真,韩镇辉,等. DNA与2-甲基-1,4-萘醌三重态相互作用生成阴、阳离子自由基对的直接检测[J]. 辐射研究与辐射工艺学报,2000(03).
APA 马建华,林维真,韩镇辉,姚思德,&林念芸.(2000).DNA与2-甲基-1,4-萘醌三重态相互作用生成阴、阳离子自由基对的直接检测.辐射研究与辐射工艺学报(03).
MLA 马建华,et al."DNA与2-甲基-1,4-萘醌三重态相互作用生成阴、阳离子自由基对的直接检测".辐射研究与辐射工艺学报 .03(2000).
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