醋炔诺酮肟及醋炔诺酮在兔体内的药代动力学研究

CAS OpenIR > 中科院上海原子核所2003年前

	醋炔诺酮肟及醋炔诺酮在兔体内的药代动力学研究
	庞雪冰
	1989-12-27
Source Publication	同济医科大学学报
Issue	06
Abstract	本文应用[~3H)标记化合物。采用高效液相(HPLC)反相色谱及放射检测技术;研究了醋炔诺酮肟(NETO-AC);醋炔诺酮(NET-AC)经口给药后在兔体内的药代动力学过程。实验结果表明;NETO-AC和NET-AC在兔体内迅速吸收并水解;原型药NETO-AC和含乙酰基的代谢产物NET-AC的血浓甚低;而不含乙酰基的代谢产物炔诺酮肟(NETO)和炔诺酮(NET)的血浓较高;后二者是NETO-AC在兔体内发挥药理作用的主要形式;其体内处置方式符合口服二室模型。
Indexed By	CNKI
Language	中文
Funding Project	原子核所项目组
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/11213
Collection	中科院上海原子核所2003年前
Recommended Citation GB/T 7714	庞雪冰. 醋炔诺酮肟及醋炔诺酮在兔体内的药代动力学研究[J]. 同济医科大学学报,1989(06).
APA	庞雪冰.(1989).醋炔诺酮肟及醋炔诺酮在兔体内的药代动力学研究.同济医科大学学报(06).
MLA	庞雪冰."醋炔诺酮肟及醋炔诺酮在兔体内的药代动力学研究".同济医科大学学报 .06(1989).

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