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干扰素—γ对胃癌细胞肿瘤坏死因子受休的调控
冉瑞琼; 孙建中; 吴裕炘; 付华; 王国平; 曹世龙
1997-08-15
Source Publication中国病理生理杂志
Issue04
Abstract为了探讨干扰素-γ对胃癌细胞(SGC_(7901))肿瘤坏死因子(TNF)受体的影响及干扰素—γ肿瘤坏死因子突变体(TNF—m)协同抗肿瘤的机制;以_(125)I-肿瘤坏死因子突变体(~(123)I—TNF—m)为配体;用放射配体结合分析法研究了干扰素-γ对SGC_(7901)细胞TNF受体表达及TNF—m内化和降解的影响。外用MTT法研究了干扰素-γ与TNF-m协同抗肿瘤作用。结果表明:干扰素-γ使SGC_(7901)细胞TNF受体数目由0.56×10~(-11) nmol/细胞增加到0.94×10~(-11)nmol/细胞(P<0.01);而对受体亲和力无影响(kd值:2.78×10~(-10)mol对2.64×10~(-10) mol.P>0.5);干扰素-γ可明显增加TNF—m内化和降解的绝对数量而对其比率无影响。干扰素-γ使TNF—m对SGC_(7901)细胞的最大杀伤率由60.48%上升到96.76%(P<0.01)。提示:干扰素-γ通过上调TNF受体而加强TNF—m的体外抗肿瘤作用。
Indexed ByCNKI
Language中文
Funding Project原子核所项目组
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/11410
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
冉瑞琼,孙建中,吴裕炘,等. 干扰素—γ对胃癌细胞肿瘤坏死因子受休的调控[J]. 中国病理生理杂志,1997(04).
APA 冉瑞琼,孙建中,吴裕炘,付华,王国平,&曹世龙.(1997).干扰素—γ对胃癌细胞肿瘤坏死因子受休的调控.中国病理生理杂志(04).
MLA 冉瑞琼,et al."干扰素—γ对胃癌细胞肿瘤坏死因子受休的调控".中国病理生理杂志 .04(1997).
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