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抗胶质瘤免疫放疗制剂~(35)S标记单抗SZ39细胞毒效应
兰青; 黄强; 庄道玲; 吴元芳; 孙志方
1998-05-30
Source Publication中华微生物学和免疫学杂志
Issue03
Abstract目的证实新制备的纯β射线免疫放疗制剂35S-McAbSZ39对胶质瘤的特异性杀伤作用。方法采用MTT法;以人脑胶质瘤细胞系SHG-44为靶细胞;检测35S-McAbSZ39及其对照组35S-nIgG;35S+McAbSZ39;35S持续作用组的细胞杀伤率;求取50%细胞抑制浓度。结果35S-McAbSZ39的细胞杀伤力与35S持续作用相近;较35S-nIgG强4.2倍;较35S+McAbSZ39强4.0倍(P<0.05)。结论35S-McAbSZ39具有高效的靶选择性细胞毒效应;作为一种免疫放疗制剂具有良好的应用前景。
Indexed ByCNKI
Language中文
Funding Project原子核所项目组
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/11708
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
兰青,黄强,庄道玲,等. 抗胶质瘤免疫放疗制剂~(35)S标记单抗SZ39细胞毒效应[J]. 中华微生物学和免疫学杂志,1998(03).
APA 兰青,黄强,庄道玲,吴元芳,&孙志方.(1998).抗胶质瘤免疫放疗制剂~(35)S标记单抗SZ39细胞毒效应.中华微生物学和免疫学杂志(03).
MLA 兰青,et al."抗胶质瘤免疫放疗制剂~(35)S标记单抗SZ39细胞毒效应".中华微生物学和免疫学杂志 .03(1998).
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