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炔诺酮肟(NETO)与炔诺酮(NET)在猴体内的药代动力学
傅官铭; 左明达; 李敦周; 周美英; 赵夏令; 王国平; 魏振年; 王训立; 李志雄
1991-01-31
Source Publication药学学报
Issue01
Abstract利用HPLC分离和液闪测定放射性的方法;研究了恒河猴ⅳ和鼻饲NETO和NET的药代动力学。鼻饲后NETO和NET吸收迅速;24 h内均基本消除。鼻饲或ⅳNETO后;一部分迅速转变为NET;一部分以原药形式存在。两药的血药浓度—时间曲线符合po或ⅳ的二室开放模型。二原药的主要药代动力学参数无显著差异。NETO与NET的鼻饲绝对生物利用度分別为64.46±34.60与35.02±26.49%。
Indexed ByCNKI
Language中文
Funding Project原子核所项目组
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/11894
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714		 傅官铭,左明达,李敦周,等. 炔诺酮肟(NETO)与炔诺酮(NET)在猴体内的药代动力学[J]. 药学学报,1991(01).
APA 傅官铭.,左明达.,李敦周.,周美英.,赵夏令.,...&李志雄.(1991).炔诺酮肟(NETO)与炔诺酮(NET)在猴体内的药代动力学.药学学报(01).
MLA 傅官铭,et al."炔诺酮肟(NETO)与炔诺酮(NET)在猴体内的药代动力学".药学学报 .01(1991).
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