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神经受体显像剂溴(~(77)Br)代螺环哌啶醇前体合成及放射性标记研究
黄永学; 李永键
1994-04-10
Source Publication核技术
Issue04
Abstract完成了一种七步化学合成得到前体螺环哌啶醇的方法;并用H2O2-冰醋酸氧化标记法和TLC纸层析法分离合成了溴(~77Br)代螺环哌啶醇。标记率为92%;放射化学产率为78%;产品的放射化学纯度>95%。并对该放射性药物在小白鼠脑内的吸收分布作了初步研究;结果表明在大脑纹状体中的摄取率可高出小脑6倍.
Indexed ByCNKI
Language中文
Funding Project原子核所项目组
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/11968
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
黄永学,李永键. 神经受体显像剂溴(~(77)Br)代螺环哌啶醇前体合成及放射性标记研究[J]. 核技术,1994(04).
APA 黄永学,&李永键.(1994).神经受体显像剂溴(~(77)Br)代螺环哌啶醇前体合成及放射性标记研究.核技术(04).
MLA 黄永学,et al."神经受体显像剂溴(~(77)Br)代螺环哌啶醇前体合成及放射性标记研究".核技术 .04(1994).
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