CAS OpenIR  > 中科院上海原子核所2003年前
兔口服炔诺酮肟和炔诺酮的药代动力学
刘洁; 庞雪冰; 李敦周; 周美英; 赵夏令; 王国平
1989
Source Publication药学学报
Issue03
Abstract本文用高效液相色谱分离、液闪测定放射性的方法;测定了兔口服炔诺酮肟(NETO)和炔诺酮(NET)的血浓;并比较了二者的药代动力学参数。结果表明:二者吸收迅速;从血中的消除均呈快慢两个时相。NETO在兔体内一部分迅速转变为NET;另一部分则以原药形式存在;24 h内NETO与其代谢产物NET在血清中的浓度大致各占一半。兔口服NETO与NET后;血浓—时间曲线符合二室模型;NETO的达峰时间比NET短;二者有显著差异(P<0.05);其它动力学参数无明显差异(P>0.05)。
Indexed ByCNKI
Language中文
Funding Project原子核所项目组
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/12081
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
刘洁,庞雪冰,李敦周,等. 兔口服炔诺酮肟和炔诺酮的药代动力学[J]. 药学学报,1989(03).
APA 刘洁,庞雪冰,李敦周,周美英,赵夏令,&王国平.(1989).兔口服炔诺酮肟和炔诺酮的药代动力学.药学学报(03).
MLA 刘洁,et al."兔口服炔诺酮肟和炔诺酮的药代动力学".药学学报 .03(1989).
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