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用~2H-苯丙氨酸示踪和GC-MS分析技术测定人体内苯丙氨酸-4-羟化酶活力
戴腾昌; 夏宗勤; 张建华; 胡雅儿; 陆汉明; 李宣海; 彭孝伟; 施强华; 徐信容; 黄光禄; 秦燕; 施晓谋; 庄道玲; 马喆
1992
Source Publication同位素
Issue01
Abstract采用~2H-苯丙氨酸(~2H-Phenylalanine)负荷试验;对8例正常人和23例肝硬化病人(8例代偿性;15例失代偿)的苯丙氨酸羟化酶活力进行了测定。单次静脉注射L-~2H-Phe(10mg/kg体重)或DL-~2H-Phe(20mg/kg体重)后;用GC-MS法分析血浆~2H-Phe和~2H-Tyrosine的丰度。苯丙氨酸羟化酶的活力用4种方式表达:①~2H-Tyr丰度的上升斜率。②~2H-Tyr/~2H-Phe丰度比的上升斜率。③~2H-Tyr丰度时相曲线下的面积。④~2H-Tyr/~2H-Phe丰度比时相曲线下的面积。实验结果表明:代偿性肝硬化病人的苯丙氨酸羟化酶活力低于正常人;失代偿肝硬化病人的该酶活力又低于代偿性肝硬病人。
Indexed ByCNKI
Language中文
Funding Project原子核所项目组
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/12268
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
戴腾昌,夏宗勤,张建华,等. 用~2H-苯丙氨酸示踪和GC-MS分析技术测定人体内苯丙氨酸-4-羟化酶活力[J]. 同位素,1992(01).
APA 戴腾昌.,夏宗勤.,张建华.,胡雅儿.,陆汉明.,...&马喆.(1992).用~2H-苯丙氨酸示踪和GC-MS分析技术测定人体内苯丙氨酸-4-羟化酶活力.同位素(01).
MLA 戴腾昌,et al."用~2H-苯丙氨酸示踪和GC-MS分析技术测定人体内苯丙氨酸-4-羟化酶活力".同位素 .01(1992).
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