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左旋咪唑预防钩虫幼虫经肤感染的研究
胡亚凤; 王懋溥; 姚丽英; 余内逊; 施晓华; 李惠源; 沈其元; 王守仁; 郑根香; 俞淑青; 丁占初
1987
Source Publication中国寄生虫学与寄生虫病杂志
Issue01
Abstract本文报告左旋咪唑外用预防钩虫感染的持久性的机理。钩虫幼虫经涂有0.5%或1.5%左旋咪唑(下称左剂)小鼠皮肤的浸液处理后1周或3周内;丧失侵肤能力。鼠肤涂1.5%~3H—左剂后3d内;皮肤含药量迅速下降;以后速度变慢;渐趋稳定;4~5周后;尚可测到微量。药物集中在涂药局部皮肤;药液浓度高者;皮肤含药量也高;皮肤给药后局部药浓度远高于口服给药。提示左剂皮肤给药的代谢转化速率较口服给药的为低;保持生物活性的时间也较长。
Indexed ByCNKI
Language中文
Funding Project原子核所项目组
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/12479
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
胡亚凤,王懋溥,姚丽英,等. 左旋咪唑预防钩虫幼虫经肤感染的研究[J]. 中国寄生虫学与寄生虫病杂志,1987(01).
APA 胡亚凤.,王懋溥.,姚丽英.,余内逊.,施晓华.,...&丁占初.(1987).左旋咪唑预防钩虫幼虫经肤感染的研究.中国寄生虫学与寄生虫病杂志(01).
MLA 胡亚凤,et al."左旋咪唑预防钩虫幼虫经肤感染的研究".中国寄生虫学与寄生虫病杂志 .01(1987).
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