CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
DNA Nanostructure-Decorated Surfaces for Enhanced Aptamer-Target Binding and Electrochemical Cocaine Sensors
Wen, YL; Pei, H; Wan, Y; Su, Y; Huang, Q(黄庆); Song, SP(宋世平); Fan, CH(樊春海)
2011
Source PublicationANALYTICAL CHEMISTRY
ISSN0003-2700
Volume83Issue:19Pages:7418
AbstractThe sensitivity of aptamer-based electrochemical sensors is often limited by restricted target accessibility and surface-induced perturbation of the aptamer structure, which arise from imperfect packing of probes on the heterogeneous and locally crowded surface. In this study, we have developed an ultrasensitive and highly selective electrochemical aptamer-based cocaine sensor (EACS), based on a DNA nanotechnology-based sensing platform. We have found that the electrode surface decorated with an aptamer probe-pendant tetrahedral DNA nanostructure greatly facilitates cocaine-induced fusion of the split anticocaine aptamer. This novel design leads to a sensitive cocaine sensor with a remarkably low detection limit of 33 nM. It is also important that the tetrahedra-decorated surface is protein-resistant, which not only suits the enzyme-based signal amplification scheme employed in this work, but ensures high selectivity of this sensor when deployed in sera or other adulterated samples.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000295303600027
Citation statistics
Cited Times:183[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/12856
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Wen, YL,Pei, H,Wan, Y,et al. DNA Nanostructure-Decorated Surfaces for Enhanced Aptamer-Target Binding and Electrochemical Cocaine Sensors[J]. ANALYTICAL CHEMISTRY,2011,83(19):7418.
APA Wen, YL.,Pei, H.,Wan, Y.,Su, Y.,Huang, Q.,...&Fan, CH.(2011).DNA Nanostructure-Decorated Surfaces for Enhanced Aptamer-Target Binding and Electrochemical Cocaine Sensors.ANALYTICAL CHEMISTRY,83(19),7418.
MLA Wen, YL,et al."DNA Nanostructure-Decorated Surfaces for Enhanced Aptamer-Target Binding and Electrochemical Cocaine Sensors".ANALYTICAL CHEMISTRY 83.19(2011):7418.
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