CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Gold nanoparticles for high-throughput genotyping of long-range haplotypes
Chen, P; Pan, D(潘敦); Fan, CH(樊春海); Chen, JH; Huang, K; Wang, DF; Zhang, HL; Li, Y; Feng, GY; Liang, PJ; He, L; Shi, YY
2011
Source PublicationNATURE NANOTECHNOLOGY
ISSN1748-3387
Volume6Issue:10Pages:639
AbstractCompletion of the Human Genome Project(1) and the HapMap Project(2) has led to increasing demands for mapping complex traits in humans to understand the aetiology of diseases(3). Identifying variations in the DNA sequence, which affect how we develop disease and respond to pathogens and drugs, is important for this purpose, but it is difficult to identify these variations in large sample sets(3-5). Here we show that through a combination of capillary sequencing and polymerase chain reaction assisted by gold nanoparticles, it is possible to identify several DNA variations that are associated with age-related macular degeneration(6-8) and psoriasis(9) on significant regions of human genomic DNA. Our method is accurate and promising for large-scale and high-throughput genetic analysis of susceptibility towards disease and drug resistance(10-12).
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000295923800012
Citation statistics
Cited Times:91[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/12863
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Chen, P,Pan, D,Fan, CH,et al. Gold nanoparticles for high-throughput genotyping of long-range haplotypes[J]. NATURE NANOTECHNOLOGY,2011,6(10):639.
APA Chen, P.,Pan, D.,Fan, CH.,Chen, JH.,Huang, K.,...&Shi, YY.(2011).Gold nanoparticles for high-throughput genotyping of long-range haplotypes.NATURE NANOTECHNOLOGY,6(10),639.
MLA Chen, P,et al."Gold nanoparticles for high-throughput genotyping of long-range haplotypes".NATURE NANOTECHNOLOGY 6.10(2011):639.
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