CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmium-containing quantum dots
Su, YY; Peng, F; Jiang, ZY; Zhong, YL; Lu, YM; Jiang, XX; Huang, Q(黄庆); Fan, CH(樊春海); Lee, ST; He, Y
2011
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume32Issue:25Pages:5855
AbstractFluorescent II-IV Quantum dots (QDs) have demonstrated to be highly promising biological probes for various biological and biomedical applications due to their many attractive merits, such as robust photostabilty, strong photoluminescence, and size-tunable fluorescence. Along with wide ranging bioapplications, concerns about their biosafety have attracted increasingly intensive attentions. In comparison to full investigation of in vitro toxicity, there has been only scanty information regarding in vivo toxicity of the QDs. Particularly, while in vivo toxicity of organic synthesized QDs (orQDs) have been investigated recently, there exist no comprehensive studies concerning in vivo behavior of aqueous synthesized QDs (aqQDs) up to present. Herein, we investigate short- and long-term in vivo biodistribution, pharmacokinetics, and toxicity of the aqQDs. Particularly, the aqQDs are initially accumulated in liver after short-time (0.5-4 h) post-injection, and then are increasingly absorbed by kidney during long-time (15-80 days) blood circulation. Moreover, obviously size-dependent biodistribution is observed: aqQDs with larger sizes are more quickly accumulated in the spleen. Furthermore, histological and biochemical analysis, and body weight measurement demonstrate that there is no overt toxicity of aqQDs in mice even at long-time exposure time. Our studies provide invaluable information for the design and development of aqQDs for biological and biomedical applications. (C) 2011 Elsevier Ltd. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000292714700013
Citation statistics
Cited Times:126[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/12865
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Su, YY,Peng, F,Jiang, ZY,et al. In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmium-containing quantum dots[J]. BIOMATERIALS,2011,32(25):5855.
APA Su, YY.,Peng, F.,Jiang, ZY.,Zhong, YL.,Lu, YM.,...&He, Y.(2011).In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmium-containing quantum dots.BIOMATERIALS,32(25),5855.
MLA Su, YY,et al."In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmium-containing quantum dots".BIOMATERIALS 32.25(2011):5855.
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