Nanographene oxide labeling with Re-188

CAS OpenIR > 中科院上海应用物理研究所2011-2020年

	Nanographene oxide labeling with Re-188
	Zhang, XY（张小勇）; Li, J; Zhu, Y（诸颖）; Qi, YJ（漆玉金）; Zhu, ZY（朱智勇）; Li, WX（李文新）; Huang, Q（黄庆）
	2011
Source Publication	NUCLEAR SCIENCE AND TECHNIQUES
ISSN	1001-8042
Volume	22 Issue:2 Pages:99
Abstract	Nanographene oxide (NGO) is currently being explored for various biomedical applications. However, little information is known about its biological behaviors in vitro and in vivo. For further studying its pharmacokinetics and related biological behaviors in living systems, an effective and convenient tracing method is particularly demanded. In this work, NGO was labeled with radionuclide Re-188 (Re-188-NGO). To obtain high labeling yield and purity, a number of labeling conditions, including concentration of SnCl2 and ascorbic acid, reaction time and temperature, and pH were optimized, and stability of the Re-188-NGO in vitro and in vivo was evaluated. The results showed that NGO could be effectively labeled with high yield. The purified Re-188-NGO showed high stability in vitro and in vivo. A pretest of NGO biodistribution with single photon emission computed tomography showed that the Re-188-NGO was rapidly taken by organs such as lungs, liver, and spleen. The biodistribution of Re-188-NGO differs significantly from the free radionuclide, indicating that the labeling procedure is highly suitable for investigating its biological behavior in living systems.
Indexed By	SCI
Language	英语
Funding Project	应物所项目组
WOS ID	WOS:000291843700007
Citation statistics	Cited Times:7[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/12868
Collection	中科院上海应用物理研究所2011-2020年
Recommended Citation GB/T 7714	Zhang, XY,Li, J,Zhu, Y,et al. Nanographene oxide labeling with Re-188[J]. NUCLEAR SCIENCE AND TECHNIQUES,2011,22(2):99.
APA	Zhang, XY.,Li, J.,Zhu, Y.,Qi, YJ.,Zhu, ZY.,...&Huang, Q.(2011).Nanographene oxide labeling with Re-188.NUCLEAR SCIENCE AND TECHNIQUES,22(2),99.
MLA	Zhang, XY,et al."Nanographene oxide labeling with Re-188".NUCLEAR SCIENCE AND TECHNIQUES 22.2(2011):99.

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