CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Nanographene oxide labeling with Re-188
Zhang, XY(张小勇); Li, J; Zhu, Y(诸颖); Qi, YJ(漆玉金); Zhu, ZY(朱智勇); Li, WX(李文新); Huang, Q(黄庆)
AbstractNanographene oxide (NGO) is currently being explored for various biomedical applications. However, little information is known about its biological behaviors in vitro and in vivo. For further studying its pharmacokinetics and related biological behaviors in living systems, an effective and convenient tracing method is particularly demanded. In this work, NGO was labeled with radionuclide Re-188 (Re-188-NGO). To obtain high labeling yield and purity, a number of labeling conditions, including concentration of SnCl2 and ascorbic acid, reaction time and temperature, and pH were optimized, and stability of the Re-188-NGO in vitro and in vivo was evaluated. The results showed that NGO could be effectively labeled with high yield. The purified Re-188-NGO showed high stability in vitro and in vivo. A pretest of NGO biodistribution with single photon emission computed tomography showed that the Re-188-NGO was rapidly taken by organs such as lungs, liver, and spleen. The biodistribution of Re-188-NGO differs significantly from the free radionuclide, indicating that the labeling procedure is highly suitable for investigating its biological behavior in living systems.
Indexed BySCI
Funding Project应物所项目组
WOS IDWOS:000291843700007
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Document Type期刊论文
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GB/T 7714
Zhang, XY,Li, J,Zhu, Y,et al. Nanographene oxide labeling with Re-188[J]. NUCLEAR SCIENCE AND TECHNIQUES,2011,22(2):99.
APA Zhang, XY.,Li, J.,Zhu, Y.,Qi, YJ.,Zhu, ZY.,...&Huang, Q.(2011).Nanographene oxide labeling with Re-188.NUCLEAR SCIENCE AND TECHNIQUES,22(2),99.
MLA Zhang, XY,et al."Nanographene oxide labeling with Re-188".NUCLEAR SCIENCE AND TECHNIQUES 22.2(2011):99.
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