CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Protein Corona-Mediated Mitigation of Cytotoxicity of Graphene Oxide
Hu, WB; Peng, C(彭程); Lv, M(吕敏); Li, XM; Zhang, YJ; Chen, N; Fan, CH(樊春海); Huang, Q(黄庆)
2011
Source PublicationACS NANO
ISSN1936-0851
Volume5Issue:5Pages:3693
AbstractGraphene is a single layer of sp(2)-bonded carbons that has unique and highly attractive electronic, mechanical, and thermal properties. Consequently, the potential impact of graphene and its derivatives (e.g., graphene oxide, GO) on human and environmental health has raised considerable concerns. In this study, we have carried out a systematic investigation on cellular effects of GO nanosheets and identified the effect of fetal bovine serum (FBS), an often-employed component in cell culture medium, on the cytotoxicity of GO. At low concentrations of FBS (1%), human cells were sensitive to the presence of GO and showed concentration-dependent cytotoxicity. Interestingly, the cytotoxicity of GO was greatly mitigated at 10% FBS, the concentration usually employed In cell medium. Our studies have demonstrated that the cytotoxicity of GO nanosheets arises from direct Interactions between the cell membrane and GO nanosheets that result in physical damage to the cell membrane. This effect is largely attenuated when GO is incubated with FBS due to the extremely high protein adsorption ability of GO. The observation of this FBS-mitigated GO cytotoxicity effect may provide an alternative and convenient route to engineer nanomaterials for safe biomedical and environmental applications.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000290826800034
Citation statistics
Cited Times:487[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/12875
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Hu, WB,Peng, C,Lv, M,et al. Protein Corona-Mediated Mitigation of Cytotoxicity of Graphene Oxide[J]. ACS NANO,2011,5(5):3693.
APA Hu, WB.,Peng, C.,Lv, M.,Li, XM.,Zhang, YJ.,...&Huang, Q.(2011).Protein Corona-Mediated Mitigation of Cytotoxicity of Graphene Oxide.ACS NANO,5(5),3693.
MLA Hu, WB,et al."Protein Corona-Mediated Mitigation of Cytotoxicity of Graphene Oxide".ACS NANO 5.5(2011):3693.
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