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Pulmonary Epithelial CCR3 Promotes LPS-Induced Lung Inflammation by Mediating Release of IL-8
Li, B(李波); Dong, CL; Wang, GF; Zheng, HR; Wang, XD; Bai, CX
2011
Source PublicationJOURNAL OF CELLULAR PHYSIOLOGY
ISSN0021-9541
Volume226Issue:9Pages:2398
AbstractInterleukin (IL)-8 from pulmonary epithelial cells has been suggested to play an important role in the airway inflammation, although the mechanism remains unclear. We envisioned a possibility that pulmonary epithelial CCR3 could be involved in secretion and regulation of IL-8 and promote lipopolysaccharide (LPS)-induced lung inflammation. Human bronchial epithelial cell line NCI-H292 and alveolar type II epithelial cell line A549 were used to test role of CCR3 in production of IL-8 at cellular level. In vivo studies were performed on C57/BL6 mice instilled intratracheally with LPS in a model of acute lung injury (ALI). The activity of a CCR3-specific inhibitor (SB-328437) was measured in both in vitro and in vivo systems. We found that expression of CCR3 in NCI-H292 and A549 cells were increased by 23% and 16%, respectively, 24 h after the challenge with LPS. LPS increased the expression of CCR3 in NCI-H292 and A549 cells in a time-dependent manner, which was inhibited significantly by SB-328437. SB-328437 also diminished neutrophil recruitment in alveolar airspaces and improved LPS-induced ALI and production of IL-8 in bronchoalveolar lavage fluid. These results suggest that pulmonary epithelial CCR3 be involved in progression of LPS-induced lung inflammation by mediating release of IL-8. CCR3 in pulmonary epithelia may be an attractive target for development of therapies for ALI. J. Cell. Physiol. J. Cell. Physiol. 226: 2398-2405, 2011. (C) 2010 Wiley-Liss, Inc.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000291689700022
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/12876
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Li, B,Dong, CL,Wang, GF,et al. Pulmonary Epithelial CCR3 Promotes LPS-Induced Lung Inflammation by Mediating Release of IL-8[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2011,226(9):2398.
APA Li, B,Dong, CL,Wang, GF,Zheng, HR,Wang, XD,&Bai, CX.(2011).Pulmonary Epithelial CCR3 Promotes LPS-Induced Lung Inflammation by Mediating Release of IL-8.JOURNAL OF CELLULAR PHYSIOLOGY,226(9),2398.
MLA Li, B,et al."Pulmonary Epithelial CCR3 Promotes LPS-Induced Lung Inflammation by Mediating Release of IL-8".JOURNAL OF CELLULAR PHYSIOLOGY 226.9(2011):2398.
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