Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids

CAS OpenIR > 中科院上海应用物理研究所2011-2020年

	Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids
	Gao, AR; Lu, N; Dai, PF; Li, T; Pei, H; Gao, XL; Gong, YB; Wang, YL; Fan, CH（樊春海）
	2011
Source Publication	NANO LETTERS
ISSN	1530-6984
Volume	11 Issue:9 Pages:3974
Abstract	We herein report the design of a novel semiconducting silicon nanowire field-effect transistor (SiNW-FET) biosensor array for ultrasensitive label-free and real-time detection of nucleic acids. Highly responsive SiNWs with narrow sizes and high surface-to-volume-ratios were "top-down" fabricated with a complementary metal oxide semiconductor compatible anisotropic self-stop etching technique. When SiNWs were covalently modified with DNA probes, the nanosensor showed highly sensitive concentration-dependent conductance change in response to specific target DNA sequences. This SiNW-FET nanosensor revealed ultrahigh sensitivity for rapid and reliable detection of 1 fM of target DNA and high specificity single-nucleotide polymorphism discrimination. As a proof-of-concept for multiplex detection with this small-size and mass producible sensor array, we demonstrated simultaneous selective detection of two pathogenic strain virus DNA sequences (H1N1 and H5N1) of avian influenza.
Indexed By	SCI
Language	英语
Funding Project	应物所项目组
WOS ID	WOS:000294790200080
Citation statistics	Cited Times:186[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/12879
Collection	中科院上海应用物理研究所2011-2020年
Recommended Citation GB/T 7714	Gao, AR,Lu, N,Dai, PF,et al. Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids[J]. NANO LETTERS,2011,11(9):3974.
APA	Gao, AR.,Lu, N.,Dai, PF.,Li, T.,Pei, H.,...&Fan, CH.(2011).Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids.NANO LETTERS,11(9),3974.
MLA	Gao, AR,et al."Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids".NANO LETTERS 11.9(2011):3974.

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