Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids | |
Gao, AR; Lu, N; Dai, PF; Li, T; Pei, H; Gao, XL; Gong, YB; Wang, YL; Fan, CH(樊春海) | |
2011 | |
Source Publication | NANO LETTERS
![]() |
ISSN | 1530-6984 |
Volume | 11Issue:9Pages:3974 |
Abstract | We herein report the design of a novel semiconducting silicon nanowire field-effect transistor (SiNW-FET) biosensor array for ultrasensitive label-free and real-time detection of nucleic acids. Highly responsive SiNWs with narrow sizes and high surface-to-volume-ratios were "top-down" fabricated with a complementary metal oxide semiconductor compatible anisotropic self-stop etching technique. When SiNWs were covalently modified with DNA probes, the nanosensor showed highly sensitive concentration-dependent conductance change in response to specific target DNA sequences. This SiNW-FET nanosensor revealed ultrahigh sensitivity for rapid and reliable detection of 1 fM of target DNA and high specificity single-nucleotide polymorphism discrimination. As a proof-of-concept for multiplex detection with this small-size and mass producible sensor array, we demonstrated simultaneous selective detection of two pathogenic strain virus DNA sequences (H1N1 and H5N1) of avian influenza. |
Indexed By | SCI |
Language | 英语 |
Funding Project | 应物所项目组 |
WOS ID | WOS:000294790200080 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.sinap.ac.cn/handle/331007/12879 |
Collection | 中科院上海应用物理研究所2011-2020年 |
Recommended Citation GB/T 7714 | Gao, AR,Lu, N,Dai, PF,et al. Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids[J]. NANO LETTERS,2011,11(9):3974. |
APA | Gao, AR.,Lu, N.,Dai, PF.,Li, T.,Pei, H.,...&Fan, CH.(2011).Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids.NANO LETTERS,11(9),3974. |
MLA | Gao, AR,et al."Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids".NANO LETTERS 11.9(2011):3974. |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
Silicon-Nanowire-Bas(2691KB) | 开放获取 | License | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment