CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids
Gao, AR; Lu, N; Dai, PF; Li, T; Pei, H; Gao, XL; Gong, YB; Wang, YL; Fan, CH(樊春海)
2011
Source PublicationNANO LETTERS
ISSN1530-6984
Volume11Issue:9Pages:3974
AbstractWe herein report the design of a novel semiconducting silicon nanowire field-effect transistor (SiNW-FET) biosensor array for ultrasensitive label-free and real-time detection of nucleic acids. Highly responsive SiNWs with narrow sizes and high surface-to-volume-ratios were "top-down" fabricated with a complementary metal oxide semiconductor compatible anisotropic self-stop etching technique. When SiNWs were covalently modified with DNA probes, the nanosensor showed highly sensitive concentration-dependent conductance change in response to specific target DNA sequences. This SiNW-FET nanosensor revealed ultrahigh sensitivity for rapid and reliable detection of 1 fM of target DNA and high specificity single-nucleotide polymorphism discrimination. As a proof-of-concept for multiplex detection with this small-size and mass producible sensor array, we demonstrated simultaneous selective detection of two pathogenic strain virus DNA sequences (H1N1 and H5N1) of avian influenza.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000294790200080
Citation statistics
Cited Times:179[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/12879
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Gao, AR,Lu, N,Dai, PF,et al. Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids[J]. NANO LETTERS,2011,11(9):3974.
APA Gao, AR.,Lu, N.,Dai, PF.,Li, T.,Pei, H.,...&Fan, CH.(2011).Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids.NANO LETTERS,11(9),3974.
MLA Gao, AR,et al."Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids".NANO LETTERS 11.9(2011):3974.
Files in This Item: Download All
File Name/Size DocType Version Access License
Silicon-Nanowire-Bas(2691KB) 开放获取LicenseView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Gao, AR]'s Articles
[Lu, N]'s Articles
[Dai, PF]'s Articles
Baidu academic
Similar articles in Baidu academic
[Gao, AR]'s Articles
[Lu, N]'s Articles
[Dai, PF]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Gao, AR]'s Articles
[Lu, N]'s Articles
[Dai, PF]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.