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| Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90 | |
| Li, Jian（李健）; Sun, Lihua（孙丽华）; Xu, Chunyan（徐春艳）; Yu, Feng（郁峰）; Zhou, Huan; Zhao, Yanlong; Zhang, Jian; Cai, Jianhua; Mao, Cheney; Tang, Lin（唐琳）; Xu, Yechun; He, Jianhua（何建华） | |
| 2012 | |
| Source Publication | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| ISSN | 1672-9145 |
| Volume | 44Issue:4Pages:300 |
| Abstract | The activation of molecular chaperone heat-shock protein 90 (Hsp90) is dependent on ATP binding and hydrolysis, which occurs in the N-terminal domains of protein. Here, we have determined three crystal structures of the N-terminal domain of human Hsp90 in native and in complex with ATP and ATP analog, providing a clear view of the catalytic mechanism of ATP hydrolysis by Hsp90. Additionally, the binding of ATP leads the N-terminal domains to be an intermediate state that could be used to partially explain why the isolated N-terminal domain of Hsp90 has very weak ATP hydrolytic activity. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000302297500003 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/12915 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Li, Jian,Sun, Lihua,Xu, Chunyan,et al. Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2012,44(4):300. |
| APA | Li, Jian.,Sun, Lihua.,Xu, Chunyan.,Yu, Feng.,Zhou, Huan.,...&He, Jianhua.(2012).Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,44(4),300. |
| MLA | Li, Jian,et al."Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 44.4(2012):300. |
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