Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| A Graphene Nanoprobe for Rapid, Sensitive, and Multicolor Fluorescent DNA Analysis | |
| He, SJ（何世江）; Song, B（宋波）; Li, D（李迪）; Zhu, CF; Qi, WP（亓文鹏）; Wen, YQ; Wang, LH（王丽华）; Song, SP（宋世平）; Fang, HP（方海平）; Fan, CH（樊春海） | |
| 2010 | |
| Source Publication | ADVANCED FUNCTIONAL MATERIALS
 |
| ISSN | 1616-301X |
| Volume | 20Issue:3Pages:453 |
| Abstract | Coupling nanomaterials with biomolecular recognition events represents a new direction in nanotechnology toward the development of novel molecular diagnostic tools. Here a graphene oxide (GO)-based multicolor fluorescent DNA nanoprobe that allows rapid, sensitive, and selective detection of DNA targets in homogeneous solution by exploiting interactions between GO and DNA molecules is reported. Because of the extraordinarily high quenching efficiency of GO, the fluorescent ssDNA probe exhibits minimal background fluorescence, while strong emission is observed when it forms a double helix with the specific targets, leading to a high signal-to-background ratio. Importantly, the large planar surface of GO allows simultaneous quenching of multiple DNA probes labeled with different dyes, leading to a multicolor sensor for the detection of multiple DNA targets in the same solution. It is also demonstrated that this GO-based sensing platform is suitable for the detection of a range of analytes when complemented with the use of functional DNA structures. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000274644400011 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13022 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Recommended Citation GB/T 7714 | He, SJ,Song, B,Li, D,et al. A Graphene Nanoprobe for Rapid, Sensitive, and Multicolor Fluorescent DNA Analysis[J]. ADVANCED FUNCTIONAL MATERIALS,2010,20(3):453. |
| APA | He, SJ.,Song, B.,Li, D.,Zhu, CF.,Qi, WP.,...&Fan, CH.(2010).A Graphene Nanoprobe for Rapid, Sensitive, and Multicolor Fluorescent DNA Analysis.ADVANCED FUNCTIONAL MATERIALS,20(3),453. |
| MLA | He, SJ,et al."A Graphene Nanoprobe for Rapid, Sensitive, and Multicolor Fluorescent DNA Analysis".ADVANCED FUNCTIONAL MATERIALS 20.3(2010):453. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| A Graphene Nanoprobe（658KB） | 开放获取 | License | View Application Full Text | |||
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