Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| A graphene-enhanced molecular beacon for homogeneous DNA detection | |
| Li, F; Huang, Y; Yang, Q; Zhong, ZT; Li, D（李迪）; Wang, LH（王丽华）; Song, SP（宋世平）; Fan, CH（樊春海） | |
| 2010 | |
| Source Publication | NANOSCALE
 |
| ISSN | 2040-3364 |
| Volume | 2Issue:6Pages:1021 |
| Abstract | In this work, we report the design of a novel graphene-based molecular beacon (MB) that could sensitively and selectively detect specific DNA sequences. The ability of water-soluble graphene oxide (GO) to differentiated hairpin and dsDNA offered a new approach to detect DNA. We found that the background fluorescence of MB was significantly suppressed in the presence of GO, which increased the signal-to-background ratio, hence the sensitivity. Moreover, the single-mismatch differentiation ability of hairpin DNA was maintained, leading to high selectivity of this new method. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000278588300029 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13024 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Recommended Citation GB/T 7714 | Li, F,Huang, Y,Yang, Q,et al. A graphene-enhanced molecular beacon for homogeneous DNA detection[J]. NANOSCALE,2010,2(6):1021. |
| APA | Li, F.,Huang, Y.,Yang, Q.,Zhong, ZT.,Li, D.,...&Fan, CH.(2010).A graphene-enhanced molecular beacon for homogeneous DNA detection.NANOSCALE,2(6),1021. |
| MLA | Li, F,et al."A graphene-enhanced molecular beacon for homogeneous DNA detection".NANOSCALE 2.6(2010):1021. |
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