CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
A graphene-enhanced molecular beacon for homogeneous DNA detection
Li, F; Huang, Y; Yang, Q; Zhong, ZT; Li, D(李迪); Wang, LH(王丽华); Song, SP(宋世平); Fan, CH(樊春海)
2010
Source PublicationNANOSCALE
ISSN2040-3364
Volume2Issue:6Pages:1021
AbstractIn this work, we report the design of a novel graphene-based molecular beacon (MB) that could sensitively and selectively detect specific DNA sequences. The ability of water-soluble graphene oxide (GO) to differentiated hairpin and dsDNA offered a new approach to detect DNA. We found that the background fluorescence of MB was significantly suppressed in the presence of GO, which increased the signal-to-background ratio, hence the sensitivity. Moreover, the single-mismatch differentiation ability of hairpin DNA was maintained, leading to high selectivity of this new method.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000278588300029
Citation statistics
Cited Times:190[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13024
Collection中科院上海应用物理研究所2004-2010年
Recommended Citation
GB/T 7714
Li, F,Huang, Y,Yang, Q,et al. A graphene-enhanced molecular beacon for homogeneous DNA detection[J]. NANOSCALE,2010,2(6):1021.
APA Li, F.,Huang, Y.,Yang, Q.,Zhong, ZT.,Li, D.,...&Fan, CH.(2010).A graphene-enhanced molecular beacon for homogeneous DNA detection.NANOSCALE,2(6),1021.
MLA Li, F,et al."A graphene-enhanced molecular beacon for homogeneous DNA detection".NANOSCALE 2.6(2010):1021.
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