CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
An Electrochemically Actuated Reversible DNA Switch
Yang, Y; Liu, G; Liu, HJ; Li, D(李迪); Fan, CH(樊春海); Liu, DS
Source PublicationNANO LETTERS
AbstractIn this Letter, we have realized the electrical actuation of a DNA molecular device in a rapid and reliable manner with a microfabricated chip. The three-electrode chip containing Ir, IrO(2), and Ag electrodes deposited in designed shapes and positions on the SiO(2) surface was made by photolithography and magnetron reaction sputter deposition technology. In this design, the negative feedback property enabled the system to rapidly change and maintain the solution pH at arbitrary value by water electrolysis. As a proof-of-concept, we can drive a DNA switch based on the opening and close of an i-motif structure by switching the potential between the working and reference electrodes between -304 and -149 mV. We have demonstrated that DNA can be electrically switched within seconds, without obvious decay of the fluorescence amplitudes for at least 30 cycles, suggesting that this DNA switch is rapid in response and fairly robust. We have also demonstrated that this device could manipulate the DNA switch automatically by using chronoamperometry.
Indexed BySCI
Funding Project应物所项目组
WOS IDWOS:000276557100053
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Document Type期刊论文
Recommended Citation
GB/T 7714
Yang, Y,Liu, G,Liu, HJ,et al. An Electrochemically Actuated Reversible DNA Switch[J]. NANO LETTERS,2010,10(4):1393.
APA Yang, Y,Liu, G,Liu, HJ,Li, D,Fan, CH,&Liu, DS.(2010).An Electrochemically Actuated Reversible DNA Switch.NANO LETTERS,10(4),1393.
MLA Yang, Y,et al."An Electrochemically Actuated Reversible DNA Switch".NANO LETTERS 10.4(2010):1393.
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