CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Cellular uptake and cytotoxic evaluation of fullerenol in different cell lines
Su, YY; Xu, JY; Shen, PP; Li, J; Wang, LH(王丽华); Li, QN(李晴暖); Li, WX(李文新); Xu, GT; Fan, CH(樊春海); Huang, Q(黄庆)
2010
Source PublicationTOXICOLOGY
ISSN0300-483X
Volume269Issue:41308Pages:155
AbstractWe reported the studies of aggregation, cellular uptake and cytotoxicity of C(60)(OH)(x), one of important water-soluble fullerene derivatives. The results showed C(60)(OH)(x) was smaller in size but harder to go into cells in the media with serum. Moreover, C(60)(OH)(x) showed severe toxicity to Chinese hamster lung and Chinese hamster ovary cells, but almost no effect on L929 cells, which implied that the cytotoxicity of C(60)(OH)(x) was cell type specific. Flow cytometry was used to examine the precise effect of C(60)(OH)(x) on the cell cycle and found cells was blocked at G1 phase. These results are expected to be helpful to understand the toxicity of fullerene derivatives. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000277063900008
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13032
Collection中科院上海应用物理研究所2004-2010年
Recommended Citation
GB/T 7714
Su, YY,Xu, JY,Shen, PP,et al. Cellular uptake and cytotoxic evaluation of fullerenol in different cell lines[J]. TOXICOLOGY,2010,269(41308):155.
APA Su, YY.,Xu, JY.,Shen, PP.,Li, J.,Wang, LH.,...&Huang, Q.(2010).Cellular uptake and cytotoxic evaluation of fullerenol in different cell lines.TOXICOLOGY,269(41308),155.
MLA Su, YY,et al."Cellular uptake and cytotoxic evaluation of fullerenol in different cell lines".TOXICOLOGY 269.41308(2010):155.
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