Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Cellular uptake and cytotoxic evaluation of fullerenol in different cell lines | |
| Su, YY; Xu, JY; Shen, PP; Li, J; Wang, LH(王丽华）; Li, QN（李晴暖）; Li, WX（李文新）; Xu, GT; Fan, CH（樊春海）; Huang, Q（黄庆） | |
| 2010 | |
| Source Publication | TOXICOLOGY
 |
| ISSN | 0300-483X |
| Volume | 269Issue:41308Pages:155 |
| Abstract | We reported the studies of aggregation, cellular uptake and cytotoxicity of C(60)(OH)(x), one of important water-soluble fullerene derivatives. The results showed C(60)(OH)(x) was smaller in size but harder to go into cells in the media with serum. Moreover, C(60)(OH)(x) showed severe toxicity to Chinese hamster lung and Chinese hamster ovary cells, but almost no effect on L929 cells, which implied that the cytotoxicity of C(60)(OH)(x) was cell type specific. Flow cytometry was used to examine the precise effect of C(60)(OH)(x) on the cell cycle and found cells was blocked at G1 phase. These results are expected to be helpful to understand the toxicity of fullerene derivatives. (C) 2009 Elsevier Ireland Ltd. All rights reserved. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000277063900008 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13032 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Recommended Citation GB/T 7714 | Su, YY,Xu, JY,Shen, PP,et al. Cellular uptake and cytotoxic evaluation of fullerenol in different cell lines[J]. TOXICOLOGY,2010,269(41308):155. |
| APA | Su, YY.,Xu, JY.,Shen, PP.,Li, J.,Wang, LH.,...&Huang, Q.(2010).Cellular uptake and cytotoxic evaluation of fullerenol in different cell lines.TOXICOLOGY,269(41308),155. |
| MLA | Su, YY,et al."Cellular uptake and cytotoxic evaluation of fullerenol in different cell lines".TOXICOLOGY 269.41308(2010):155. |
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