CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Nanodiamonds as intracellular transporters of chemotherapeutic drug
Li, J; Zhu, Y(诸颖); Li, WX(李文新); Zhang, XY(张小勇); Peng, Y; Huang, Q(黄庆)
2010
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume31Issue:32Pages:8410
AbstractTo explore the application of nanodiamonds (NDs) as anticancer drug delivery vehicles, firstly we examined the toxicity of NDs to three kinds of mammalian cells. The studies indicated that serum proteins in cell culture medium had significant effect. When cells were exposed to NDs dispersed in complete cell culture medium, no cytotoxicity was detected. However, severe cell death was found after exposed to NDs dispersed in serum-free medium. Possible reasons for serum-dependent cytotoxicity were discussed and the potential influence of serum on the test of efficacy was pointed for anticancer drug delivery system based on NDs. Then adsorption of anticancer drug 10-hydroxycamptothecin (HCPT) by NDs was studied. Experiments indicated that diluted NaOH solution could promote the loading of HCPT on NDs. And a slow release of HCPT from the HCPT-ND complex was established in low pH media. Assessments of cell viability and imaging with transmission electron microscopy demonstrated a much higher efficacy of the HCPT-ND complex compared with HCPT alone. On the basis of adsorption feature of ND aggregates, new strategy for the design of targeting drug delivery systems of NDs was proposed. (C) 2010 Elsevier Ltd. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000283112700032
Citation statistics
Cited Times:156[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13047
Collection中科院上海应用物理研究所2004-2010年
Recommended Citation
GB/T 7714
Li, J,Zhu, Y,Li, WX,et al. Nanodiamonds as intracellular transporters of chemotherapeutic drug[J]. BIOMATERIALS,2010,31(32):8410.
APA Li, J,Zhu, Y,Li, WX,Zhang, XY,Peng, Y,&Huang, Q.(2010).Nanodiamonds as intracellular transporters of chemotherapeutic drug.BIOMATERIALS,31(32),8410.
MLA Li, J,et al."Nanodiamonds as intracellular transporters of chemotherapeutic drug".BIOMATERIALS 31.32(2010):8410.
Files in This Item: Download All
File Name/Size DocType Version Access License
Nanodiamonds as intr(1449KB) 开放获取LicenseView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, J]'s Articles
[Zhu, Y(诸颖)]'s Articles
[Li, WX(李文新)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, J]'s Articles
[Zhu, Y(诸颖)]'s Articles
[Li, WX(李文新)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, J]'s Articles
[Zhu, Y(诸颖)]'s Articles
[Li, WX(李文新)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Nanodiamonds as intracellular transporters of chemotherapeutic drug.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.