The polyhydroxylated fullerene derivative C-60(OH)(24) protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction

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	The polyhydroxylated fullerene derivative C-60(OH)(24) protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction
	Cai, XQ（蔡小青）; Hao, JJ; Zhang, XY（张小勇）; Yu, BZ（于伯章）; Ren, JM; Luo, C; Li, QN（李晴暖）; Huang, Q（黄庆）; Shi, XL; Li, WX（李文新）; Liu, JK
	2010
Source Publication	TOXICOLOGY AND APPLIED PHARMACOLOGY
ISSN	0041-008X
Volume	243 Issue:1 Pages:27
Abstract	Although the protective effect of the polyhydroxylated fullerene derivative C-60(OH)(n) against ionizing radiation is an area of much interest, the mechanisms relating to how polyhydroxylated fullerene derivatives improve mitochondrial dysfunction remain unknown. In order to find new and effective radioprotective agents, we synthesized a new polyhydroxylated fullerene molecule with 24 hydroxyl groups of known positions on C-60 and studied its protective effects in mice subjected to irradiation. Mice were pretreated with C-60(OH)(24) for 2 weeks (daily, 40 mg/kg i. p.), then subjected to a lethal dose of whole body gamma-irradiation (from a Co-60 source). Survival was observed for 30 days after irradiation. Immune and mitochondrial dysfunction and oxidative damage were analyzed in mice with the same C-60(OH)(24) pretreatment and irradiation except that the animals were euthanized at day 5 after the irradiation. It was found that 2-week C-60(OH)(24) pretreatment effectively reduced whole body irradiation-induced mortality without apparent toxicity. C-60(OH)(24) pretreatment also showed significant protective effects against ionizing-radiation-induced decreases in immune and mitochondrial function and antioxidant defense in the liver and spleen. These results suggest that the polyhydroxylated fullerene derivative C-60(OH)(24) protects against ionizing-radiation-induced mortality, possibly by enhancing immune function, decreasing oxidative damage and improving mitochondrial function. (C) 2009 Elsevier Inc. All rights reserved.
Indexed By	SCI
Language	英语
Funding Project	应物所项目组
WOS ID	WOS:000274489700004
Citation statistics	Cited Times:59[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/13059
Collection	中科院上海应用物理研究所2004-2010年
Recommended Citation GB/T 7714	Cai, XQ,Hao, JJ,Zhang, XY,et al. The polyhydroxylated fullerene derivative C-60(OH)(24) protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2010,243(1):27.
APA	Cai, XQ.,Hao, JJ.,Zhang, XY.,Yu, BZ.,Ren, JM.,...&Liu, JK.(2010).The polyhydroxylated fullerene derivative C-60(OH)(24) protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction.TOXICOLOGY AND APPLIED PHARMACOLOGY,243(1),27.
MLA	Cai, XQ,et al."The polyhydroxylated fullerene derivative C-60(OH)(24) protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction".TOXICOLOGY AND APPLIED PHARMACOLOGY 243.1(2010):27.

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