CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond
Zhang, XY(张小勇); Hu, WB; Li, J(李晶); Tao, L; Wei, Y
2012
Source PublicationTOXICOLOGY RESEARCH
ISSN2045-452X
Volume1Issue:1
AbstractInvestigations of the interactions between carbon nanomaterials (CNMs) and living organisms and their subsequent biological responses are of fundamental significance for toxicity assessment and further biomedical applications. In this work, the cellular uptake and cytotoxicity of multi-walled carbon nanotubes (MWCNTs), graphene oxide (GO) and nanodiamond (ND) were examined and compared. We demonstrated that all of the CNMs were readily internalized by HeLa cells through nonspecific cellular uptake. Their cell uptake ratios showed significant differences in the following order: ND > MWCNTs > GO. A series of biological assays were used to evaluate the cytotoxicity of CNMs. It was found that CNMs showed dose- and time-dependent cytotoxicity to HeLa cells. However, cytotoxicity of CNMs was not associated with their cell uptake ratios. Among them, ND exhibited the highest cell uptake ratio and the least cytotoxicity. To the best of our knowledge, this is the first study which has quantitatively determined and compared the cell uptake ratios and cytotoxicities of MWCNTs, GO and ND. And we expect that these results described here could provide useful information for the development of new strategies to design efficient drug delivery nanocarriers and therapeutic systems as well as deep insights into the mechanism of CNMs' cytotoxicity.
Language英语
Funding Project应物所项目组
WOS IDWOS:000315731500008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13071
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Zhang, XY,Hu, WB,Li, J,et al. A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond[J]. TOXICOLOGY RESEARCH,2012,1(1).
APA Zhang, XY,Hu, WB,Li, J,Tao, L,&Wei, Y.(2012).A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond.TOXICOLOGY RESEARCH,1(1).
MLA Zhang, XY,et al."A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond".TOXICOLOGY RESEARCH 1.1(2012).
Files in This Item:
File Name/Size DocType Version Access License
A comparative study (1680KB) 开放获取LicenseView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, XY(张小勇)]'s Articles
[Hu, WB]'s Articles
[Li, J(李晶)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, XY(张小勇)]'s Articles
[Hu, WB]'s Articles
[Li, J(李晶)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, XY(张小勇)]'s Articles
[Hu, WB]'s Articles
[Li, J(李晶)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.