CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers
Pei, H; Li, J; Lv, M(吕敏); Wang, JY(王靖琰); Gao, JM; Lu, JX; Li, YP(李勇平); Huang, Q(黄庆); Hu, J(胡钧); Fan, CH(樊春海)
2012
Source PublicationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN0002-7863
Volume134Issue:33
AbstractIn this work, we report a new concept of adaptive "ensemble aptamers" (ENSaptamers) that exploits the collective recognition abilities of a small set of rationally designed, nonspecific DNA sequences to identify molecular or cellular targets discriminatively. In contrast to in vitro selected aptamers, which possess specific "lock-and-key" recognition, ENSaptamers rely on pattern recognition that mimics natural olfactory or gustatory systems. Nanographene oxide was employed to provide a low-background and highly reproducible fluorescent assay system. We demonstrate that this platform provides a highly discriminative and adaptive tool for high precision identification of a wide range of targets for diagnostic and proteomic applications with a nearly unlimited supply of ENSaptamer receptors.
Language英语
Funding Project应物所项目组
WOS IDWOS:000307699000045
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13074
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Pei, H,Li, J,Lv, M,et al. A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2012,134(33).
APA Pei, H.,Li, J.,Lv, M.,Wang, JY.,Gao, JM.,...&Fan, CH.(2012).A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,134(33).
MLA Pei, H,et al."A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 134.33(2012).
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