Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers | |
| Pei, H; Li, J; Lv, M（吕敏）; Wang, JY（王靖琰）; Gao, JM; Lu, JX; Li, YP（李勇平）; Huang, Q（黄庆）; Hu, J（胡钧）; Fan, CH（樊春海） | |
| 2012 | |
| Source Publication | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| ISSN | 0002-7863 |
| Volume | 134Issue:33 |
| Abstract | In this work, we report a new concept of adaptive "ensemble aptamers" (ENSaptamers) that exploits the collective recognition abilities of a small set of rationally designed, nonspecific DNA sequences to identify molecular or cellular targets discriminatively. In contrast to in vitro selected aptamers, which possess specific "lock-and-key" recognition, ENSaptamers rely on pattern recognition that mimics natural olfactory or gustatory systems. Nanographene oxide was employed to provide a low-background and highly reproducible fluorescent assay system. We demonstrate that this platform provides a highly discriminative and adaptive tool for high precision identification of a wide range of targets for diagnostic and proteomic applications with a nearly unlimited supply of ENSaptamer receptors. |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000307699000045 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13074 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Pei, H,Li, J,Lv, M,et al. A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2012,134(33). |
| APA | Pei, H.,Li, J.,Lv, M.,Wang, JY.,Gao, JM.,...&Fan, CH.(2012).A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,134(33). |
| MLA | Pei, H,et al."A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 134.33(2012). |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| A Graphene-Based Sen（2189KB） | 开放获取 | License | View Application Full Text | |||
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