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A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers | |
Pei, H; Li, J; Lv, M(吕敏); Wang, JY(王靖琰); Gao, JM; Lu, JX; Li, YP(李勇平); Huang, Q(黄庆); Hu, J(胡钧); Fan, CH(樊春海) | |
2012 | |
Source Publication | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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ISSN | 0002-7863 |
Volume | 134Issue:33 |
Abstract | In this work, we report a new concept of adaptive "ensemble aptamers" (ENSaptamers) that exploits the collective recognition abilities of a small set of rationally designed, nonspecific DNA sequences to identify molecular or cellular targets discriminatively. In contrast to in vitro selected aptamers, which possess specific "lock-and-key" recognition, ENSaptamers rely on pattern recognition that mimics natural olfactory or gustatory systems. Nanographene oxide was employed to provide a low-background and highly reproducible fluorescent assay system. We demonstrate that this platform provides a highly discriminative and adaptive tool for high precision identification of a wide range of targets for diagnostic and proteomic applications with a nearly unlimited supply of ENSaptamer receptors. |
Language | 英语 |
Funding Project | 应物所项目组 |
WOS ID | WOS:000307699000045 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.sinap.ac.cn/handle/331007/13074 |
Collection | 中科院上海应用物理研究所2011-2020年 |
Recommended Citation GB/T 7714 | Pei, H,Li, J,Lv, M,et al. A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2012,134(33). |
APA | Pei, H.,Li, J.,Lv, M.,Wang, JY.,Gao, JM.,...&Fan, CH.(2012).A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,134(33). |
MLA | Pei, H,et al."A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 134.33(2012). |
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