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A study of the radiosynthesis of fac-[Re-188(CO)(3)(H2O)(3)](+) and its application in labeling 1,2,3-triazole analogs obtained by click chemistry
Wang, C(王成); Zhou, W(周伟); Yu, JF(于俊峰); Zhang, L(张岚); Wang, N(王妮)
2012
Source PublicationNUCLEAR MEDICINE COMMUNICATIONS
ISSN0143-3636
Volume33Issue:1
AbstractObjectives To optimize the conditions for the preparation of the organometallic precursor fac-[Re-188(CO)(3)(H2O)(3)](+) and to synthesize the radiolabeling compounds of tricarbonyl rhenium. 1,2,3-Triazole analogs were synthesized by click chemistry and labeled with fac[ Re(CO)(3)(H2O)(3)]Br and fac-[Re-188(CO)(3)(H2O)(3)](+). The aim was to improve the methods for the synthesis of 188 Re-labeled radiopharmaceuticals for therapy. Methods With potassium boranocarbonate as the CO source and ammonia borane as the reducing agent, fac-[188 Re(CO) 3(H2O) 3] + was synthesized, and the click chemistry method was used to prepare the tricarbonyl rhenium complex. Results At the optimal reaction condition (the amounts of K-2[H3BCO2] and BH3 center dot NH3 are 5 and 5 mg, respectively; reaction temperature is 75 degrees C; and reaction time is 15 min), the radiochemical yields were 90%, and the labeling yield of bis(pyridin-2-ylmethyl) amine with fac-[Re-188(CO)(3)(H2O)(3)](+) was more than 99% in 1 h at 758C; the conjugation yields of triazole analog obtained by click chemistry with 'cold' and 'radio' tricarbonyl rhenium were more than 80%. Conclusion The organometallic precursor fac-[188 Re(CO) 3(H2O) 3] + was prepared under optimal reaction conditions with a yield of 90%, and the triazole analogs synthesized by click chemistry were suitable ligands for tricarbonyl rhenium. Nucl Med Commun 33:84-89 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Language英语
Funding Project应物所项目组
WOS IDWOS:000298850000012
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13081
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Wang, C,Zhou, W,Yu, JF,et al. A study of the radiosynthesis of fac-[Re-188(CO)(3)(H2O)(3)](+) and its application in labeling 1,2,3-triazole analogs obtained by click chemistry[J]. NUCLEAR MEDICINE COMMUNICATIONS,2012,33(1).
APA Wang, C,Zhou, W,Yu, JF,Zhang, L,&Wang, N.(2012).A study of the radiosynthesis of fac-[Re-188(CO)(3)(H2O)(3)](+) and its application in labeling 1,2,3-triazole analogs obtained by click chemistry.NUCLEAR MEDICINE COMMUNICATIONS,33(1).
MLA Wang, C,et al."A study of the radiosynthesis of fac-[Re-188(CO)(3)(H2O)(3)](+) and its application in labeling 1,2,3-triazole analogs obtained by click chemistry".NUCLEAR MEDICINE COMMUNICATIONS 33.1(2012).
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