CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes
Wang, ZW; Zhang, LJ(张立娟); Guo, Z(郭智); Liu, L; Ji, J; Zhang, JN; Chen, XH; Liu, BY; Zhang, J; Ding, QL; Wang, XF; Zhao, W; Zhu, ZG; Yu, YY
2012
Source PublicationPLOS ONE
ISSN1932-6203
Volume7Issue:11
AbstractIron deficiency anemia is an extra-stomach disease experienced in H. pylori carriers. Individuals with type A blood are more prone to suffering from H. pylori infection than other individuals. To clarify the molecular mechanisms underlying H. pylori-associated anemia, we collected erythrocytes from A, B, O, and AB blood donors and analyzed morphology, the number of erythrocytes with H. pylori colonies attached to them, and iron contents in erythrocytes and H. pylori (NCTC11637 and SS1 strains) by means of optical microscopy, scanning electron microscopy, and synchrotron radiation soft X-ray imaging. The number of type A erythrocytes with H. pylori attached to them was significantly higher than that of other erythrocytes (P<0.05). Far more iron distribution was observed in H. pylori bacteria using dual energy analysis near the iron L2, 3 edges by soft X-ray imaging. Iron content was significantly reduced in host erythrocytes after 4 hours of exposure to H. pylori. H. pylori are able to adhere more strongly to type A erythrocytes, and this is related to iron shift from the host to the bacteria. This may explain the reasons for refractory iron deficiency anemia and elevated susceptibility to H. pylori infection in individuals with type A blood.
Language英语
Funding Project应物所项目组
WOS IDWOS:000311821000217
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13084
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Wang, ZW,Zhang, LJ,Guo, Z,et al. A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes[J]. PLOS ONE,2012,7(11).
APA Wang, ZW.,Zhang, LJ.,Guo, Z.,Liu, L.,Ji, J.,...&Yu, YY.(2012).A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes.PLOS ONE,7(11).
MLA Wang, ZW,et al."A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes".PLOS ONE 7.11(2012).
Files in This Item: Download All
File Name/Size DocType Version Access License
A Unique Feature of (1461KB) 开放获取LicenseView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, ZW]'s Articles
[Zhang, LJ(张立娟)]'s Articles
[Guo, Z(郭智)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, ZW]'s Articles
[Zhang, LJ(张立娟)]'s Articles
[Guo, Z(郭智)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, ZW]'s Articles
[Zhang, LJ(张立娟)]'s Articles
[Guo, Z(郭智)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.