CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila
Wang, B; Chen, N(陈楠); Wei, YL; Li, J(李江); Sun, L; Wu, JR; Huang, Q(黄庆); Liu, C; Fan, CH(樊春海); Song, HY
2012
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume2
AbstractGold nanoparticles (AuNPs) are often used as vehicles to deliver drugs or biomolecules, due to their mild effect on cell survival and proliferation. However, little is known about their effect on cellular metabolism. Here we examine the in vivo effect of AuNPs on metabolism using Drosophila as a model. Drosophila and vertebrates possess similar basic metabolic functions, and a highly conserved PI3K/Akt/mTOR signaling pathway plays a central role in the regulation of energy metabolism in both organisms. We show that dietary AuNPs enter the fat body, a key metabolic tissue in Drosophila larvae. Significantly, larvae fed with AuNP show increased lipid levels without triggering stress responses. In addition, activities of the PI3K/Akt/mTOR signaling pathway and fatty acids synthesis are increased in these larvae. This study thus reveals a novel function of AuNPs in influencing animal metabolism and suggests its potential therapeutic applications for metabolic disorders.
Language英语
Funding Project应物所项目组
WOS IDWOS:000307874600003
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13087
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Wang, B,Chen, N,Wei, YL,et al. Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila[J]. SCIENTIFIC REPORTS,2012,2.
APA Wang, B.,Chen, N.,Wei, YL.,Li, J.,Sun, L.,...&Song, HY.(2012).Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila.SCIENTIFIC REPORTS,2.
MLA Wang, B,et al."Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila".SCIENTIFIC REPORTS 2(2012).
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