CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Bone-Prognostic Status After Cessation of Cadmium Exposure for One Month in Male Rats
Chen, X; Zhu, GY; Jin, TY; Shao, CL; Gu, SZ; Tan, MG(谈明光); Zhang, YY; Xiao, HF; Hu, HP; Yu, YZ
2012
Source PublicationARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
ISSN0090-4341
Volume62Issue:1
AbstractThis study investigated bone status after decreased cadmium (Cd) exposure in male rats. Sprague-Dawley male rats were randomly divided into three groups. One group was injected subcutaneously with sodium chloride as control. The others were given CdCl(2) by subcutaneous injection at doses of 0.5 mg Cd/kg body weight (bw) for 2 months (Cd+2m) and for 3 months (Cd+3m). For the Cd+2m group, the rats were shifted to cessation of Cd injection for 1 month after 2 months' exposure. At month 3, micro-computed tomography (micro-CT) analyses were performed on the proximal tibia and lumbar spine, and urine was collected from all rats. Rats were then killed and blood collected for metabolic-marker measurement and Cd assay. Bone tissues were also collected for bone-mass assay, biomechanical test, and bone-histology analysis. Cd burdens of rats in the Cd+2m and Cd+3m groups were both significantly greater than those in the control group. Cd burdens of rats were lower in the Cd+2m group compared with the Cd+3m group. Bone damage occurred in the Cd+2m and Cd+3m groups compared with the control group (p < 0.05), but no significant improvement was found in the Cd+2m group compared with the Cd+3m group. Cd damage to bone could not be reversed over the short term. More attention should be paid to Cd's toxic effects on bone after decreased exposure.
Language英语
Funding Project应物所项目组
WOS IDWOS:000298501600019
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13099
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Chen, X,Zhu, GY,Jin, TY,et al. Bone-Prognostic Status After Cessation of Cadmium Exposure for One Month in Male Rats[J]. ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,2012,62(1).
APA Chen, X.,Zhu, GY.,Jin, TY.,Shao, CL.,Gu, SZ.,...&Yu, YZ.(2012).Bone-Prognostic Status After Cessation of Cadmium Exposure for One Month in Male Rats.ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,62(1).
MLA Chen, X,et al."Bone-Prognostic Status After Cessation of Cadmium Exposure for One Month in Male Rats".ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 62.1(2012).
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