Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Cytotoxicity of Phenol Red in Toxicity Assays for Carbon Nanoparticles | |
| Zhu, Y（诸颖）; Zhang, XY（张小勇）; Zhu, JH; Zhao, QF; Li, YG（李宇国）; Li, WX（李文新）; Fan, CH（樊春海）; Huang, Q（黄庆） | |
| 2012 | |
| Source Publication | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| ISSN | 1422-0067 |
| Volume | 13Issue:10 |
| Abstract | To explore the novel properties of carbon nanoparticles (CNPs) in nanotoxicity assays, the adsorption of phenol red (a pH indicator for culture medium) by multi-walled carbon nanotubes (MWNTs) and three kinds of carbon blacks (CBs) with nanosize, and its effects on cytotoxicity were studied. Results indicated that the phenol red adsorbed and delivered into cells by CBs was responsible for the toxicity to Hela cells in the medium without serum. The cellular uptake of phenol red was verified using I-125-labeling techniques. The size-dependent cytotoxicity of CBs was found to closely correlate to adsorption of phenol red, cellular uptake of phenol red-CB complexes and the amount of phenol red delivered into the cells by CBs. Although the CBs were either nontoxic or slightly toxic, as vehicles of phenol red, they played an essential role in the cytotoxicity induced by phenol red. However, MWNTs showed an intrinsic cytotoxicity independent of phenol red. The implications associated with these findings are discussed. |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000310677800013 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13117 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Zhu, Y,Zhang, XY,Zhu, JH,et al. Cytotoxicity of Phenol Red in Toxicity Assays for Carbon Nanoparticles[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2012,13(10). |
| APA | Zhu, Y.,Zhang, XY.,Zhu, JH.,Zhao, QF.,Li, YG.,...&Huang, Q.(2012).Cytotoxicity of Phenol Red in Toxicity Assays for Carbon Nanoparticles.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,13(10). |
| MLA | Zhu, Y,et al."Cytotoxicity of Phenol Red in Toxicity Assays for Carbon Nanoparticles".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 13.10(2012). |
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