CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Cytotoxicity of Phenol Red in Toxicity Assays for Carbon Nanoparticles
Zhu, Y(诸颖); Zhang, XY(张小勇); Zhu, JH; Zhao, QF; Li, YG(李宇国); Li, WX(李文新); Fan, CH(樊春海); Huang, Q(黄庆)
2012
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1422-0067
Volume13Issue:10
AbstractTo explore the novel properties of carbon nanoparticles (CNPs) in nanotoxicity assays, the adsorption of phenol red (a pH indicator for culture medium) by multi-walled carbon nanotubes (MWNTs) and three kinds of carbon blacks (CBs) with nanosize, and its effects on cytotoxicity were studied. Results indicated that the phenol red adsorbed and delivered into cells by CBs was responsible for the toxicity to Hela cells in the medium without serum. The cellular uptake of phenol red was verified using I-125-labeling techniques. The size-dependent cytotoxicity of CBs was found to closely correlate to adsorption of phenol red, cellular uptake of phenol red-CB complexes and the amount of phenol red delivered into the cells by CBs. Although the CBs were either nontoxic or slightly toxic, as vehicles of phenol red, they played an essential role in the cytotoxicity induced by phenol red. However, MWNTs showed an intrinsic cytotoxicity independent of phenol red. The implications associated with these findings are discussed.
Language英语
Funding Project应物所项目组
WOS IDWOS:000310677800013
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13117
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Zhu, Y,Zhang, XY,Zhu, JH,et al. Cytotoxicity of Phenol Red in Toxicity Assays for Carbon Nanoparticles[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2012,13(10).
APA Zhu, Y.,Zhang, XY.,Zhu, JH.,Zhao, QF.,Li, YG.,...&Huang, Q.(2012).Cytotoxicity of Phenol Red in Toxicity Assays for Carbon Nanoparticles.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,13(10).
MLA Zhu, Y,et al."Cytotoxicity of Phenol Red in Toxicity Assays for Carbon Nanoparticles".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 13.10(2012).
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