CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line
Lv, M(吕敏); Zhang, YJ; Liang, L; Wei, M(魏敏); Hu, WB; Li, XM; Huang, Q(黄庆)
2012
Source PublicationNANOSCALE
ISSN2040-3364
Volume4Issue:13
AbstractGraphene oxide (GO), has created an unprecedented opportunity for development and application in biology, due to its abundant functional groups and well water solubility. Recently, the potential toxicity of GO in the environment and in humans has garnered more and more attention. In this paper, we systematically studied the cytotoxicity of GO nanosheets via examining the effect of GO on the morphology, viability and differentiation of a human neuroblastoma SH-SY5Y cell line, which was an ideal model used to study neuronal disease in vitro. The results suggested that GO had no obvious cytotoxicity at low concentration (<80 mu g mL(-1)) for 96 h, but the viability of cells exhibited dose-and time-dependent decreases at high concentration (>= 80 mu g mL(-1)). Moreover, GO did not induce apoptosis. Very interestingly, GO significantly enhanced the differentiation of SH-SY5Y induced-retinoic acid (RA) by evaluating neurite length and the expression of neuronal marker MAP2. These data provide a promising application for neurodegenerative diseases.
Language英语
Funding Project应物所项目组
WOS IDWOS:000305255600007
Citation statistics
Cited Times:112[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13138
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Lv, M,Zhang, YJ,Liang, L,et al. Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line[J]. NANOSCALE,2012,4(13).
APA Lv, M.,Zhang, YJ.,Liang, L.,Wei, M.,Hu, WB.,...&Huang, Q.(2012).Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line.NANOSCALE,4(13).
MLA Lv, M,et al."Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line".NANOSCALE 4.13(2012).
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