CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Effect of Suture Properties on Stability of Middle Cerebral Artery Occlusion Evaluated by Synchrotron Radiation Angiography
Guan, YJ; Wang, YT; Yuan, FL; Lu, HY; Ren, YQ; Xiao, TQ(肖体乔); Chen, KM; Greenberg, DA; Jin, KL; Yang, GY
2012
Source PublicationSTROKE
ISSN0039-2499
Volume43Issue:3
AbstractBackground and Purpose-The intraluminal suture technique for producing middle cerebral artery occlusion in rodents is the most commonly used method for modeling focal cerebral ischemia associated with clinical ischemic stroke. Synchrotron radiation angiography may provide a novel solution to directly monitor the success of middle cerebral artery occlusion. Methods-Twenty adult Sprague-Dawley rats for middle cerebral artery occlusion models were prepared randomly with different suture head silicone coating. In vivo imaging was performed at beam line BL13W1, Shanghai Synchrotron Radiation Facility, Shanghai, China. Results-Silicone-coated suture was superior to uncoated suture for producing consistent brain infarction. Additionally, silicone coating length was an important variable controlling the extent of the ischemic lesion: infarcts affected predominantly the caudate-putamen with large variability (<2 mm), both the cortex and caudate-putamen (2-3.3 mm), and most of the hemisphere, including the hypothalamus (>3.3 mm). Conclusions-Synchrotron radiation angiography provides a useful tool to observe hemodynamic changes after middle cerebral artery occlusion, and the physical properties of suture are critical to the success of the middle cerebral artery occlusion model. (Stroke. 2012;43:888-891.)
Language英语
Funding Project应物所项目组
WOS IDWOS:000300639400058
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13140
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Guan, YJ,Wang, YT,Yuan, FL,et al. Effect of Suture Properties on Stability of Middle Cerebral Artery Occlusion Evaluated by Synchrotron Radiation Angiography[J]. STROKE,2012,43(3).
APA Guan, YJ.,Wang, YT.,Yuan, FL.,Lu, HY.,Ren, YQ.,...&Yang, GY.(2012).Effect of Suture Properties on Stability of Middle Cerebral Artery Occlusion Evaluated by Synchrotron Radiation Angiography.STROKE,43(3).
MLA Guan, YJ,et al."Effect of Suture Properties on Stability of Middle Cerebral Artery Occlusion Evaluated by Synchrotron Radiation Angiography".STROKE 43.3(2012).
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