Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Electrochemical-Based MicroRNA Sensors | |
| Wen, YL(闻艳丽); Lin, MH(林美华); Pei, H(斐昊); Lu, N; Fan, CH(樊春海) | |
| 2012 | |
| Source Publication | PROGRESS IN CHEMISTRY
 |
| ISSN | 1005-281X |
| Volume | 24Issue:9 |
| Abstract | MicroRNAs (miRNAs) are endogenous, non-coding single-stranded RNAs that regulate gene expression via degradation or translational repression of their targeted mRNAs. MiRNAs control cell growth, differentiation and apoptosis at a post-transciptional level. Recent evidence has shown that impaired miRNAs expression correlates with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes, which provides a type of promising biomarkers for cancer diagnositics. Therefore, more and more researchers are interested in developing novel miRNAs detection methods. Because electrochemical methods are rapid, sensitive and electrochemical detectors are inexpensive and portable, there has been intense interest in developing new electrochemical sensors for miRNA detection. Here, studies on electrochemical miRNA biosensors are reviewed which contains the principle of DNA biosensor, several signal amplification technologies for biosensor, design of probe for miRNA biosensor and existing electrochemical methods for miRNA detection. |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000309485800004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13149 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Recommended Citation GB/T 7714 | Wen, YL,Lin, MH,Pei, H,et al. Electrochemical-Based MicroRNA Sensors[J]. PROGRESS IN CHEMISTRY,2012,24(9). |
| APA | Wen, YL,Lin, MH,Pei, H,Lu, N,&Fan, CH.(2012).Electrochemical-Based MicroRNA Sensors.PROGRESS IN CHEMISTRY,24(9). |
| MLA | Wen, YL,et al."Electrochemical-Based MicroRNA Sensors".PROGRESS IN CHEMISTRY 24.9(2012). |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Electrochemical-Base（459KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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