CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Electrochemical-Based MicroRNA Sensors
Wen, YL(闻艳丽); Lin, MH(林美华); Pei, H(斐昊); Lu, N; Fan, CH(樊春海)
AbstractMicroRNAs (miRNAs) are endogenous, non-coding single-stranded RNAs that regulate gene expression via degradation or translational repression of their targeted mRNAs. MiRNAs control cell growth, differentiation and apoptosis at a post-transciptional level. Recent evidence has shown that impaired miRNAs expression correlates with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes, which provides a type of promising biomarkers for cancer diagnositics. Therefore, more and more researchers are interested in developing novel miRNAs detection methods. Because electrochemical methods are rapid, sensitive and electrochemical detectors are inexpensive and portable, there has been intense interest in developing new electrochemical sensors for miRNA detection. Here, studies on electrochemical miRNA biosensors are reviewed which contains the principle of DNA biosensor, several signal amplification technologies for biosensor, design of probe for miRNA biosensor and existing electrochemical methods for miRNA detection.
Funding Project应物所项目组
WOS IDWOS:000309485800004
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Document Type期刊论文
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GB/T 7714
Wen, YL,Lin, MH,Pei, H,et al. Electrochemical-Based MicroRNA Sensors[J]. PROGRESS IN CHEMISTRY,2012,24(9).
APA Wen, YL,Lin, MH,Pei, H,Lu, N,&Fan, CH.(2012).Electrochemical-Based MicroRNA Sensors.PROGRESS IN CHEMISTRY,24(9).
MLA Wen, YL,et al."Electrochemical-Based MicroRNA Sensors".PROGRESS IN CHEMISTRY 24.9(2012).
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