CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Enhanced Sensing of Nucleic Acids with Silicon Nanowire Field Effect Transistor Biosensors
Gao, AR; Lu, N(鲁娜); Wang, YC; Dai, PF; Li, T; Gao, XL; Wang, YL; Fan, CH(樊春海)
2012
Source PublicationNANO LETTERS
ISSN1530-6984
Volume12Issue:10
AbstractSilicon nanowire (SiNW) field effect transistors (FETs) have emerged as powerful sensors for ultrasensitive, direct electrical readout, and label-free biological/chemical detection. The sensing mechanism of SiNW-FET can be understood in terms of the change in charge density at the SiNW surface after hybridization. So far, there have been limited systematic studies on fundamental factors related to device sensitivity to further make clear the overall effect on sensing sensitivity. Here, we present an analytical result for our triangle cross-section wire for predicting the sensitivity of nanowire surface-charge sensors. It was confirmed through sensing experiments that the back-gated SiNW-FET sensor had the highest percentage current response in the subthreshold regime and the sensor performance could be optimized in low buffer ionic strength and at moderate probe concentration. The optimized SiNW-FET nanosensor revealed ultrahigh sensitivity for rapid and reliable detection of target DNA with a detection limit of 0.1 fM and high specificity for single-nucleotide polymorphism discrimination. In our work, enhanced sensing of biological species by optimization of operating parameters and fundamental understanding for SiNW PET detection limit was obtained.
Language英语
Funding Project应物所项目组
WOS IDWOS:000309615000032
Citation statistics
Cited Times:123[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13151
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Gao, AR,Lu, N,Wang, YC,et al. Enhanced Sensing of Nucleic Acids with Silicon Nanowire Field Effect Transistor Biosensors[J]. NANO LETTERS,2012,12(10).
APA Gao, AR.,Lu, N.,Wang, YC.,Dai, PF.,Li, T.,...&Fan, CH.(2012).Enhanced Sensing of Nucleic Acids with Silicon Nanowire Field Effect Transistor Biosensors.NANO LETTERS,12(10).
MLA Gao, AR,et al."Enhanced Sensing of Nucleic Acids with Silicon Nanowire Field Effect Transistor Biosensors".NANO LETTERS 12.10(2012).
Files in This Item: Download All
File Name/Size DocType Version Access License
Enhanced Sensing of (2053KB) 开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Gao, AR]'s Articles
[Lu, N(鲁娜)]'s Articles
[Wang, YC]'s Articles
Baidu academic
Similar articles in Baidu academic
[Gao, AR]'s Articles
[Lu, N(鲁娜)]'s Articles
[Wang, YC]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Gao, AR]'s Articles
[Lu, N(鲁娜)]'s Articles
[Wang, YC]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Enhanced Sensing of Nucleic Acids with Silicon Nanowire Field Effect Transistor Biosensors.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.