CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Excessive Sodium Ions Delivered into Cells by Nanodiamonds: Implications for Tumor Therapy
Zhu, Y(诸颖); Li, WX(李文新); Zhang, Y; Li, J; Liang, L; Zhang, XZ(张祥志); Chen, N; Sun, YH; Chen, W; Tai, RZ(邰仁忠); Fan, CH(樊春海); Huang, Q(黄庆)
2012
Source PublicationSMALL
ISSN1613-6810
Volume8Issue:11
AbstractNanodiamonds (NDs) possess many excellent physical and chemical properties that make them attractive materials for applications in biomedicine. In this paper, the adsorption and delivery of a large amount of sodium ions into the cell interior by NDs in serum-free medium is demonstrated. The excess sodium ions inside the cells induce osmotic stresses followed by cell swelling and an increase in the intracellular levels of calcium and reactive oxygen species (ROS), which leads to severe cellular damage. In complete culture medium, however, serum proteins wrapped around the NDs effectively prevent the sodium ions from adsorbing onto the NDs, and thus the NDs show no cytotoxicity. This work is the first to elaborate on the correlation between the sodium ions adsorbed on the nanomaterials and their bio-effects. Excessive ions delivered into cells by NDs might have potential applications in tumor therapy.
Language英语
Funding Project应物所项目组
WOS IDWOS:000304817700018
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13157
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Zhu, Y,Li, WX,Zhang, Y,et al. Excessive Sodium Ions Delivered into Cells by Nanodiamonds: Implications for Tumor Therapy[J]. SMALL,2012,8(11).
APA Zhu, Y.,Li, WX.,Zhang, Y.,Li, J.,Liang, L.,...&Huang, Q.(2012).Excessive Sodium Ions Delivered into Cells by Nanodiamonds: Implications for Tumor Therapy.SMALL,8(11).
MLA Zhu, Y,et al."Excessive Sodium Ions Delivered into Cells by Nanodiamonds: Implications for Tumor Therapy".SMALL 8.11(2012).
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