CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Fc-fusion proteins: new developments and future perspectives
Czajkowsky, DM; Hu, J(胡钧); Shao, ZF; Pleass, RJ
AbstractSince the first description in 1989 of CD4-Fc-fusion antagonists that inhibit human immune deficiency virus entry into T cells, Fc-fusion proteins have been intensely investigated for their effectiveness to curb a range of pathologies, with several notable recent successes coming to market. These promising outcomes have stimulated the development of novel approaches to improve their efficacy and safety, while also broadening their clinical remit to other uses such as vaccines and intravenous immunoglobulin therapy. This increased attention has also led to non-clinical applications of Fc-fusions, such as affinity reagents in microarray devices. Here we discuss recent results and more generally applicable strategies to improve Fc-fusion proteins for each application, with particular attention to the newer, less charted areas.
Funding Project应物所项目组
WOS IDWOS:000309446200001
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GB/T 7714
Czajkowsky, DM,Hu, J,Shao, ZF,et al. Fc-fusion proteins: new developments and future perspectives[J]. EMBO MOLECULAR MEDICINE,2012,4(10).
APA Czajkowsky, DM,Hu, J,Shao, ZF,&Pleass, RJ.(2012).Fc-fusion proteins: new developments and future perspectives.EMBO MOLECULAR MEDICINE,4(10).
MLA Czajkowsky, DM,et al."Fc-fusion proteins: new developments and future perspectives".EMBO MOLECULAR MEDICINE 4.10(2012).
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