CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Genetic analysis with nanoPCR
Pan, D(潘敦); Mi, LJ(米丽娟); Huang, Q(黄庆); Hu, J(胡钧); Fan, CH(樊春海)
2012
Source PublicationINTEGRATIVE BIOLOGY
ISSN1757-9694
Volume4Issue:10
AbstractPolymerase chain reaction (PCR) has become a standard and important molecular biological technique with numerous applications in genetic analysis, forensics and in vitro diagnostics. Since its invention in the 1980s, there has been dramatic performance improvement arising from long-lasting efforts to optimize amplification conditions in both academic studies and commercial applications. More recently, a range of nanometer-sized materials including metal nanoparticles, semiconductor quantum dots, carbon nanomaterials and polymer nanoparticles, have shown unique effects in tuning amplification processes of PCR. It is proposed that these artificial nanomaterials mimic protein components in the natural DNA replication machinery in vivo. These so-called nanomaterials-assisted PCR (nanoPCR) strategies shed new light on powerful PCR with unprecedented sensitivity, selectivity and extension rate. In this review, we aim to summarize recent progress in this direction and discuss possible mechanisms for such performance improvement and potential applications in genetic analysis (particularly gene typing and haplotyping) and diagnostics.
Language英语
Funding Project应物所项目组
WOS IDWOS:000309127600001
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13174
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Pan, D,Mi, LJ,Huang, Q,et al. Genetic analysis with nanoPCR[J]. INTEGRATIVE BIOLOGY,2012,4(10).
APA Pan, D,Mi, LJ,Huang, Q,Hu, J,&Fan, CH.(2012).Genetic analysis with nanoPCR.INTEGRATIVE BIOLOGY,4(10).
MLA Pan, D,et al."Genetic analysis with nanoPCR".INTEGRATIVE BIOLOGY 4.10(2012).
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