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Immunogold labeling and X-ray fluorescence microscopy reveal enrichment ratios of Cu and Zn, metabolism of APP and amyloid-beta plaque formation in a mouse model of Alzheimer's disease
Wang, HJ; Wang, M; Wang, B; Li, M; Chen, HQ; Yu, XH(余笑寒); Yang, K(杨舸); Chai, ZF; Zhao, YL; Feng, WY
2012
Source PublicationMETALLOMICS
ISSN1756-5901
Volume4Issue:10
AbstractThe mechanism that triggers amyloid-beta (A beta) fibrillation and aggregation is still elusive. Evidence suggests that the extensional interactions of the amyloid precursor protein (APP) and A beta with transition biometals, copper (Cu) and zinc (Zn), may be key occurrences in the processes of A beta aggregation and toxicity. By using an immunogold labeling technique combined with synchrotron radiation X-ray fluorescence microprobe (SR-mu XRF) scanning analysis, the profiles of APP, A beta 42 and Cu, Zn in the brain of APP transgenic mouse with the development of the disease were characterized. This investigation provides visual, kinetic and spatial evidence of the correlation of APP and A beta-metals in AD brain sections. The visual evidence demonstrates the association of metals Cu and Zn with A beta 42 during plaque formation, which helps implicate the role of metal ion homeostasis in human AD pathology.
Language英语
Funding Project应物所项目组
WOS IDWOS:000310123100012
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13190
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Wang, HJ,Wang, M,Wang, B,et al. Immunogold labeling and X-ray fluorescence microscopy reveal enrichment ratios of Cu and Zn, metabolism of APP and amyloid-beta plaque formation in a mouse model of Alzheimer's disease[J]. METALLOMICS,2012,4(10).
APA Wang, HJ.,Wang, M.,Wang, B.,Li, M.,Chen, HQ.,...&Feng, WY.(2012).Immunogold labeling and X-ray fluorescence microscopy reveal enrichment ratios of Cu and Zn, metabolism of APP and amyloid-beta plaque formation in a mouse model of Alzheimer's disease.METALLOMICS,4(10).
MLA Wang, HJ,et al."Immunogold labeling and X-ray fluorescence microscopy reveal enrichment ratios of Cu and Zn, metabolism of APP and amyloid-beta plaque formation in a mouse model of Alzheimer's disease".METALLOMICS 4.10(2012).
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