CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography
Li, HY; Yin, XZ; Ji, JQ; Sun, LX; Shao, Q; York, P; Xiao, TQ(肖体乔); He, Y(和友); Zhang, JW
2012
Source PublicationINTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN0378-5173
Volume427Issue:2
AbstractTomographic imaging techniques are attractive tools for the visualization of the internal structural characteristics of pharmaceutical solid dosage forms. In this paper, the internal structure of the tablet core for a monolith osmotic drug delivery system, felodipine sustained-release tablet, was visualized via synchrotron radiation X-ray computed microtomography during the drug release process. The surface areas and three dimensional parameters of the tablet core were calculated based on the three dimensional reconstruction of the images. At different stages of the drug release process, the surface morphology, the hydration, the swelling, and the structure changing of the tablet, were visualized from the two dimensional monochrome X-ray images. The three dimensional volumes of the remaining tablet core correlated well with the percentages of felodipine (R = 0.9988). Also, the three dimensional surface area almost unchanged during the drug release process, which clearly demonstrated the intrinsic drug release mechanism of the osmotic drug delivery system. In conclusion, the synchrotron radiation X-ray computed microtomography, with rapid acquisition, high intensity and micro-scale spatial resolution, was found to be a useful tool for the quantitative elucidation of the intrinsic drug release kinetics and the three dimensional parameters such as surface areas of the remained core obtained by the synchrotron radiation. Thus, X-ray computed microtomography can be considered as a new and complimentary analytical tool to standard compendial pharmaceutical tests for quality control of osmotic drug delivery systems. (C) 2012 Elsevier B.V. All rights reserved.
Language英语
Funding Project应物所项目组
WOS IDWOS:000302364500016
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13216
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Li, HY,Yin, XZ,Ji, JQ,et al. Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2012,427(2).
APA Li, HY.,Yin, XZ.,Ji, JQ.,Sun, LX.,Shao, Q.,...&Zhang, JW.(2012).Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography.INTERNATIONAL JOURNAL OF PHARMACEUTICS,427(2).
MLA Li, HY,et al."Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography".INTERNATIONAL JOURNAL OF PHARMACEUTICS 427.2(2012).
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