CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
One-step radiosynthesis of 4-[18F]flouro-3-nitro-N-2-propyn-1-yl-benzamide ([18F]FNPB): a new stable aromatic porosthetic group for efficient labeling of peptides with fluorine-18
Li, YS; Liu, YQ; Zhang, L(张岚); Xu, YH
2012
Source PublicationJOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN0362-4803
Volume55Issue:6
Abstract4-[18F]flouro-3-nitro-N-2-propyn-1-yl-benzamide ([18F]FNPB) was developed as a new stable aromatic prosthetic group for more efficient click labeling of peptides. A new aromatic precursor 3,4-dinitro-N-2-propyn-1-yl-benzamide was radiofluorinated using [18F]KF/K2.2.2 followed by HPLC purification to obtain the desired product [18F]FNPB. [18F]FNPB was synthesized with a 58% radiochemical yield, a specific activity?>?350?GBq/mu mol, and radiochemical purity was exceeded 98% in 40?min. The in vitro stability studies showed no detectable radiodefluorination over 2?h in mouse plasma. The click labeling yield of three different peptides with [18F]FNPB were all above 87%. The in vitro study suggests that [18F]FNPB may be stable?in vivo and could have general application in labeling peptides with high radiochemical yield for positron emission tomography applications. Copyright (c) 2012 John Wiley & Sons, Ltd.
Language英语
Funding Project应物所项目组
WOS IDWOS:000305510200008
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13229
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Li, YS,Liu, YQ,Zhang, L,et al. One-step radiosynthesis of 4-[18F]flouro-3-nitro-N-2-propyn-1-yl-benzamide ([18F]FNPB): a new stable aromatic porosthetic group for efficient labeling of peptides with fluorine-18[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,2012,55(6).
APA Li, YS,Liu, YQ,Zhang, L,&Xu, YH.(2012).One-step radiosynthesis of 4-[18F]flouro-3-nitro-N-2-propyn-1-yl-benzamide ([18F]FNPB): a new stable aromatic porosthetic group for efficient labeling of peptides with fluorine-18.JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,55(6).
MLA Li, YS,et al."One-step radiosynthesis of 4-[18F]flouro-3-nitro-N-2-propyn-1-yl-benzamide ([18F]FNPB): a new stable aromatic porosthetic group for efficient labeling of peptides with fluorine-18".JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 55.6(2012).
Files in This Item: Download All
File Name/Size DocType Version Access License
One-step radiosynthe(254KB) 开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, YS]'s Articles
[Liu, YQ]'s Articles
[Zhang, L(张岚)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, YS]'s Articles
[Liu, YQ]'s Articles
[Zhang, L(张岚)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, YS]'s Articles
[Liu, YQ]'s Articles
[Zhang, L(张岚)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: One-step radiosynthesis of 4-[18F]flouro-3-nitro-N-2-propyn-1-yl-benzamide ([18F]FNPB)-a new stable aromatic porosthetic group for efficient labeling of peptides with fluorine-18.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.